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Catalog Number:
23013
CAS Number:
57757-57-0
Propionate de dithio-bis-succinimidyle (réactif de Lomant)
Purity:
≥ 98 % (dosage)
Synonym(s):
3,3'-Dithiobis(propionate de succinimidyle)
Documents
$75.00 /100 mg
Taille
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Informations sur le produit

Dithio-bis-succinimidyl propionate, commonly known as Lomant's Reagent, is a versatile crosslinking agent widely utilized in biochemical research and bioconjugation applications. This compound is particularly valued for its ability to form stable thioether linkages between proteins, peptides, and other biomolecules, making it an essential tool in the development of targeted drug delivery systems and protein engineering. Researchers appreciate its efficiency in facilitating the conjugation of various functional groups, which enhances the stability and efficacy of therapeutic agents.

Lomant's Reagent is especially beneficial in applications such as the preparation of antibody-drug conjugates, where precise control over the linkage between the antibody and the drug is crucial for therapeutic effectiveness. Its unique properties allow for selective modification of biomolecules, enabling the creation of complex molecular architectures that can improve the pharmacokinetics and biodistribution of drugs. With its proven track record in enhancing the performance of biopharmaceuticals, Lomant's Reagent stands out as a reliable choice for researchers aiming to innovate in the fields of drug development and molecular biology.

Numéro CAS 
57757-57-0
Formule moléculaire
C14H16N2S2O8
Poids moléculaire 
404.42
Point de fusion 
128 - 132 °C (lit.)
Informations générales
Numéro CAS 
57757-57-0
Formule moléculaire
C14H16N2S2O8
Poids moléculaire 
404.42
Point de fusion 
128 - 132 °C (lit.)
Propriétés
Informations complémentaires sur la propriété à venir prochainement !
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Sécurité et réglementation
Matières dangereuses
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Antibiotique
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Réglementé par la DEA
Non
Avertissements 
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Applications

Dithio-bis-succinimidyl propionate (Lomant's Reagent) is widely utilized in research focused on

  • Protein Cross-Linking: This compound is commonly used to create stable cross-links between proteins, which is essential in studying protein interactions and structures in biochemistry.
  • Bioconjugation: It serves as an effective tool for attaching biomolecules, such as antibodies or enzymes, to surfaces or other molecules, enhancing the functionality of diagnostic and therapeutic agents.
  • Drug Delivery Systems: Researchers leverage its properties to develop advanced drug delivery systems, allowing for targeted release of therapeutics, improving efficacy while minimizing side effects.
  • Vaccine Development: The reagent is instrumental in the formulation of vaccines by aiding in the conjugation of antigens to carriers, which can enhance immune responses.
  • Material Science: In materials research, it is used for modifying surfaces to improve adhesion and compatibility of various materials, which is crucial for developing new composite materials.

Citations