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Catalog Number:
38247
CAS Number:
52-01-7
Spironolactone
Grade:
Conforme aux spécifications USP
Purity:
97,0 - 103,0 % (HPLC)
Synonym(s):
Acide 4-Prégnène-21-oïque-17a-ol-3-one-7a-thiol g-lactone 7-acétate, Acide 7a-(acétylthio)-17a-hydroxy-3-oxoprégn-4-ène-21-carboxylique-g-lactone
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Product Information

Spironolactone is a potent diuretic and anti-androgen medication widely used in the treatment of conditions such as hypertension, heart failure, and edema. This compound functions by antagonizing aldosterone receptors, leading to increased sodium and water excretion while preserving potassium. Its unique structure allows it to effectively manage fluid retention and hypertension, making it a valuable asset in cardiovascular health. Additionally, spironolactone is employed in the management of hormonal acne and polycystic ovary syndrome (PCOS), showcasing its versatility in both medical and dermatological applications.

Researchers and healthcare professionals appreciate spironolactone for its dual action as both a diuretic and an anti-androgen, providing a multifaceted approach to treatment. Its ability to balance electrolytes while promoting diuresis sets it apart from other diuretics, making it a preferred choice in various therapeutic regimens. With ongoing studies exploring its potential benefits in other areas, spironolactone continues to hold promise for future applications in medicine.

Synonyms
Acide 4-Prégnène-21-oïque-17a-ol-3-one-7a-thiol g-lactone 7-acétate, Acide 7a-(acétylthio)-17a-hydroxy-3-oxoprégn-4-ène-21-carboxylique-g-lactone
CAS Number
52-01-7
Purity
97,0 - 103,0 % (HPLC)
Grade
Conforme aux spécifications USP
Molecular Formula
C 24 H 32 O 4 S
Molecular Weight
416.58
MDL Number
MFCD00082250
PubChem ID
5267
Melting Point
198 - 209 ?C
Appearance
Poudre cristalline blanche à blanc cassé
Optical Rotation
[a] D 20 = -41 à -45 °
Conditions
Conserver à 0 - 8 °C
General Information
Synonyms
Acide 4-Prégnène-21-oïque-17a-ol-3-one-7a-thiol g-lactone 7-acétate, Acide 7a-(acétylthio)-17a-hydroxy-3-oxoprégn-4-ène-21-carboxylique-g-lactone
CAS Number
52-01-7
Purity
97,0 - 103,0 % (HPLC)
Grade
Conforme aux spécifications USP
Molecular Formula
C 24 H 32 O 4 S
Molecular Weight
416.58
MDL Number
MFCD00082250
PubChem ID
5267
Melting Point
198 - 209 ?C
Appearance
Poudre cristalline blanche à blanc cassé
Optical Rotation
[a] D 20 = -41 à -45 °
Conditions
Conserver à 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Spironolactone is widely utilized in research focused on:

  • Cardiovascular Health: Commonly prescribed for managing conditions like hypertension and heart failure, it helps reduce fluid retention and lower blood pressure, making it essential in cardiology.
  • Hormonal Treatments: Used in treating conditions related to hormonal imbalances, such as polycystic ovary syndrome (PCOS) and certain types of acne, it acts as an anti-androgen, providing relief for patients.
  • Diuretic Applications: As a potassium-sparing diuretic, it is effective in preventing potassium loss while promoting fluid elimination, which is particularly beneficial for patients with kidney issues.
  • Research in Oncology: Investigated for its potential role in cancer treatment, particularly in hormone-sensitive cancers, it offers a promising avenue for therapeutic strategies.
  • Animal Studies: Frequently used in veterinary medicine to manage similar conditions in pets, it highlights its versatility and importance across species.

Citations