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Catalog Number:
37983
CAS Number:
65277-42-1
Kétoconazole
Grade:
Conforme aux spécifications USP
Purity:
98 - 102 % (dosage sur une base sèche)
Synonym(s):
(+/-)- cis -1-acétyl-4-[4-[[2-(2,4-dichlorophényl)-2-(imidazol-1-ylméthyl)-1,3-dioxolan-4-yl]méthoxy]phényl]pipérazine
Hazmat
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Product Information

Ketoconazole is a broad-spectrum antifungal agent widely recognized for its effectiveness in treating various fungal infections. This compound is particularly valuable in dermatology, where it is used to manage conditions such as seborrheic dermatitis, tinea infections, and candidiasis. Its mechanism of action involves inhibiting ergosterol synthesis, a crucial component of fungal cell membranes, which leads to cell death and the resolution of infections. Ketoconazole is available in various formulations, including topical creams, shampoos, and oral tablets, making it versatile for both local and systemic treatment.

In addition to its antifungal properties, Ketoconazole has shown potential in treating certain skin disorders and conditions related to excessive sebum production. Researchers are exploring its applications in the management of conditions like acne and psoriasis, highlighting its relevance in both therapeutic and cosmetic formulations. With its proven efficacy and broad application range, Ketoconazole remains a key compound in the pharmaceutical and healthcare industries, offering significant benefits to both patients and healthcare providers.

Synonyms
(+/-)- cis -1-acétyl-4-[4-[[2-(2,4-dichlorophényl)-2-(imidazol-1-ylméthyl)-1,3-dioxolan-4-yl]méthoxy]phényl]pipérazine
CAS Number
65277-42-1
Purity
98 - 102 % (dosage sur une base sèche)
Grade
Conforme aux spécifications USP
Molecular Formula
C26H28Cl2N4O4
Molecular Weight
531.43
MDL Number
MFCD00058579
PubChem ID
3823
Melting Point
150 - 155 °C (lit.)
Appearance
Poudre blanche à presque blanche
Optical Rotation
[a] D 20 = -1 à 1 ° (C = 40 mg/mL dans le méthanol)
Conditions
Conserver entre 2 et 8 °C
General Information
Synonyms
(+/-)- cis -1-acétyl-4-[4-[[2-(2,4-dichlorophényl)-2-(imidazol-1-ylméthyl)-1,3-dioxolan-4-yl]méthoxy]phényl]pipérazine
CAS Number
65277-42-1
Purity
98 - 102 % (dosage sur une base sèche)
Grade
Conforme aux spécifications USP
Molecular Formula
C26H28Cl2N4O4
Molecular Weight
531.43
MDL Number
MFCD00058579
PubChem ID
3823
Melting Point
150 - 155 °C (lit.)
Appearance
Poudre blanche à presque blanche
Optical Rotation
[a] D 20 = -1 à 1 ° (C = 40 mg/mL dans le méthanol)
Conditions
Conserver entre 2 et 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Oui
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Ketoconazole is widely utilized in research focused on:

  • Antifungal Treatments: Commonly used in dermatology, ketoconazole is effective against various fungal infections, such as athlete's foot and ringworm, providing relief and promoting skin health.
  • Shampoos for Scalp Conditions: Incorporated into medicated shampoos, it helps treat dandruff and seborrheic dermatitis by reducing fungal growth on the scalp, improving overall hair and scalp condition.
  • Hormonal Imbalance Management: In endocrinology, ketoconazole is used to manage conditions like Cushing's syndrome by inhibiting cortisol production, assisting patients in regulating hormone levels.
  • Research in Drug Development: As a model compound, it aids in the study of antifungal mechanisms and resistance, helping researchers develop more effective antifungal agents.
  • Veterinary Medicine: Utilized in treating fungal infections in animals, ketoconazole supports veterinary professionals in managing pet health, particularly for skin and systemic fungal issues.

Citations