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Catalog Number:
35337
CAS Number:
19685-09-7
10-hydroxycamptothécine
Purity:
≥ 99,5 % (HPLC)
Synonym(s):
( S -10-hydroxycamptothécine
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Product Information

10-Hydroxycamptothecin is a potent alkaloid derived from the Camptotheca acuminata tree, renowned for its significant anticancer properties. This compound is primarily recognized for its role as a topoisomerase I inhibitor, making it a valuable asset in cancer research and therapeutic applications. Its mechanism of action involves the stabilization of the topoisomerase I-DNA complex, leading to DNA damage and ultimately triggering apoptosis in cancer cells. This unique property positions 10-Hydroxycamptothecin as a promising candidate in the development of novel chemotherapeutic agents, particularly for treating various malignancies such as colorectal and lung cancers.

In addition to its anticancer applications, 10-Hydroxycamptothecin has been explored for its potential use in drug formulation due to its ability to enhance the efficacy of other therapeutic agents. Researchers are particularly interested in its role in combination therapies, where it may improve treatment outcomes and reduce resistance in cancer cells. With ongoing studies and clinical trials, the compound holds great promise for advancing cancer treatment strategies, making it a critical focus for pharmaceutical development and research initiatives.

Synonyms
( S -10-hydroxycamptothécine
CAS Number
19685-09-7
Purity
≥ 99,5 % (HPLC)
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
MDL Number
MFCD02093100
PubChem ID
4330531
Melting Point
260 - 270 ?C
Appearance
Poudre jaune ou poudre cristalline jaune
Conditions
Conserver entre 2 et 8 °C
General Information
Synonyms
( S -10-hydroxycamptothécine
CAS Number
19685-09-7
Purity
≥ 99,5 % (HPLC)
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
MDL Number
MFCD02093100
PubChem ID
4330531
Melting Point
260 - 270 ?C
Appearance
Poudre jaune ou poudre cristalline jaune
Conditions
Conserver entre 2 et 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

10-Hydroxycamptothecin is widely utilized in research focused on

  • Cancer Treatment: This compound is a potent inhibitor of topoisomerase I, making it valuable in developing anticancer therapies. It has shown effectiveness against various cancers, including colorectal and ovarian cancers.
  • Pharmaceutical Development: Researchers are exploring its derivatives to enhance solubility and bioavailability, leading to more effective drug formulations. This is crucial for improving patient outcomes in cancer therapy.
  • Drug Combination Studies: 10-Hydroxycamptothecin is often used in combination with other chemotherapeutic agents to assess synergistic effects, helping to optimize treatment regimens for better efficacy.
  • Research on Mechanisms of Action: It serves as a model compound in studies investigating the mechanisms of DNA damage and repair, contributing to a deeper understanding of cellular responses to chemotherapy.
  • Natural Product Synthesis: This compound is derived from the Camptotheca acuminata tree, and its study promotes sustainable sourcing and synthesis of natural products, appealing to eco-conscious researchers and industries.