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Catalog Number:
38123
CAS Number:
123653-11-2
NS-398
Purity:
≥ 98 % (HPLC)
Synonym(s):
N- [2-(Ciclohexiloxi)-4-nitrofenil]metanosulfonamida
Documents
$205.61 /10 mg
Tamaño
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Información del producto

NS-398 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), making it a valuable compound in both pharmaceutical research and therapeutic applications. With its unique structure, characterized by the presence of a cyclohexyloxy group and a nitrophenyl moiety, NS-398 has been extensively studied for its anti-inflammatory and analgesic properties. This compound is particularly relevant in the development of non-steroidal anti-inflammatory drugs (NSAIDs), offering a targeted approach to pain management and inflammation reduction without the gastrointestinal side effects commonly associated with traditional NSAIDs.

Researchers have utilized NS-398 in various studies to explore its efficacy in treating conditions such as arthritis, cancer, and cardiovascular diseases. Its selectivity for COX-2 over COX-1 allows for a more favorable safety profile, making it an attractive candidate for further development in pain relief therapies. The compound's ability to modulate inflammatory pathways positions it as a significant player in the ongoing search for safer and more effective anti-inflammatory agents.

Número CAS
123653-11-2
Fórmula molecular
C13H18N2O5S
Peso molecular
314.36
Número MDL
MFCD00882995
Punto de fusión
137 - 141 °C
Condiciones
Conservar entre 2 y 8 °C.
Información general
Número CAS
123653-11-2
Fórmula molecular
C13H18N2O5S
Peso molecular
314.36
Número MDL
MFCD00882995
Punto de fusión
137 - 141 °C
Condiciones
Conservar entre 2 y 8 °C.
Propiedades
¡Pronto habrá más información sobre la propiedad!
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Seguridad y normativas
Materiales peligrosos
-
Antibiótico
-
Regulado por la DEA
No
Advertencias
-
Aplicaciones

NS-398 is widely utilized in research focused on:

  • Pain Management: This compound acts as a selective inhibitor of cyclooxygenase-2 (COX-2), making it valuable in developing anti-inflammatory medications that target pain relief without the gastrointestinal side effects associated with non-selective NSAIDs.
  • Cancer Research: NS-398 has shown potential in inhibiting tumor growth in various cancer models, providing researchers with a tool to explore COX-2's role in cancer progression and the development of new therapies.
  • Cardiovascular Studies: By selectively inhibiting COX-2, NS-398 is used in studies examining its effects on cardiovascular health, helping to understand the balance between inflammation and heart disease.
  • Neuroprotection: Research indicates that NS-398 may offer neuroprotective benefits, making it a candidate for studies aimed at treating neurodegenerative diseases like Alzheimer's and Parkinson's.
  • Drug Development: As a lead compound, NS-398 serves as a model for synthesizing new COX-2 inhibitors, aiding pharmaceutical companies in creating safer and more effective anti-inflammatory drugs.

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