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Catalog Number:
29779
CAS Number:
263847-08-1
Fmoc-(4 S )-4-azido-L-prolina
Purity:
≥ 99 % (HPLC)
Synonym(s):
Fmoc-L-Pro(4-N3)-OH(2S,4S), Fmoc-(2 S ,4 S )-4-azidoprolina
Antibiotic
Documents
$100.05 /250 mg
Tamaño
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Product Information

Fmoc-(4S)-4-Azido-L-Proline is a versatile building block widely utilized in peptide synthesis and drug development. This compound features a unique azido group that allows for efficient click chemistry applications, making it an ideal choice for researchers aiming to create complex molecular architectures. Its Fmoc (fluorenylmethyloxycarbonyl) protecting group facilitates easy incorporation into peptides, enhancing the efficiency of synthesis while maintaining stability under various conditions.

This compound is particularly valuable in the fields of medicinal chemistry and bioconjugation, where it can be employed to introduce azide functionalities into peptides and proteins for subsequent labeling or modification. The ability to selectively react with alkynes in click reactions opens up possibilities for creating novel therapeutics and diagnostic agents. Researchers appreciate the compound's compatibility with standard peptide coupling methods, which streamlines the synthesis process and improves overall yields. With its unique properties and practical applications, Fmoc-(4S)-4-Azido-L-Proline stands out as an essential tool for advancing peptide-based research and development.

Synonyms
Fmoc-L-Pro(4-N3)-OH(2S,4S), Fmoc-(2 S ,4 S )-4-azidoprolina
CAS Number
263847-08-1
Purity
≥ 99 % (HPLC)
Molecular Formula
C20H18N4O4
Molecular Weight
378.39
MDL Number
MFCD04115792
PubChem ID
21467060
Appearance
Polvo cristalino de color blanco a blanquecino.
Optical Rotation
[a] D 20 = -15 ± 1 º (C=1 en DMF)
Conditions
Conservar entre 0 y 8 °C.
General Information
Synonyms
Fmoc-L-Pro(4-N3)-OH(2S,4S), Fmoc-(2 S ,4 S )-4-azidoprolina
CAS Number
263847-08-1
Purity
≥ 99 % (HPLC)
Molecular Formula
C20H18N4O4
Molecular Weight
378.39
MDL Number
MFCD04115792
PubChem ID
21467060
Appearance
Polvo cristalino de color blanco a blanquecino.
Optical Rotation
[a] D 20 = -15 ± 1 º (C=1 en DMF)
Conditions
Conservar entre 0 y 8 °C.
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
DEA-regulated
No
Warnings
-
Applications

Fmoc-(4S)-4-Azido-L-Proline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the incorporation of azide groups that facilitate further chemical modifications.
  • Bioconjugation: The azide functional group enables efficient bioconjugation reactions, such as click chemistry, which can be used to attach biomolecules, fluorescent tags, or drugs to peptides, enhancing their functionality in drug delivery systems.
  • Drug Development: In pharmaceutical research, it is used to create novel peptide-based therapeutics, leveraging its unique properties to improve bioactivity and selectivity of drug candidates.
  • Protein Engineering: Researchers utilize this compound in the design of modified proteins with azide groups, allowing for targeted modifications that can improve stability or activity in various applications.
  • Material Science: The compound is also explored in the development of smart materials, where its azido group can be used to create cross-linked networks that respond to environmental stimuli, offering innovative solutions in various industrial applications.

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