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Catalog Number:
37674
CAS Number:
153559-49-0
Bexarotene
Purity:
≥ 96% (HPLC)
Synonym(s):
Targretin
Documents
$176.26 /100MG
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Product Information

Bexarotene is a synthetic retinoid that has garnered attention for its potential applications in oncology and dermatology. This compound is primarily recognized for its role in the treatment of cutaneous T-cell lymphoma (CTCL), where it acts by modulating gene expression and promoting differentiation of malignant cells. Researchers have also explored its efficacy in various cancer types due to its ability to activate retinoid receptors, which can lead to tumor regression. Additionally, Bexarotene has shown promise in neurodegenerative disease research, particularly in Alzheimer's disease, where it may help in reducing amyloid plaque formation.

The unique structure of Bexarotene allows for selective targeting of retinoid receptors, providing a distinct advantage over traditional retinoids. This specificity may result in fewer side effects and enhanced therapeutic outcomes, making it a valuable option for both clinical and research applications. Its versatility in addressing complex diseases highlights its significance in the pharmaceutical landscape, appealing to researchers and healthcare professionals seeking innovative solutions.

Synonyms
Targretin
CAS Number
153559-49-0
Purity
≥ 96% (HPLC)
Molecular Formula
C24H28O2
Molecular Weight
348.49
MDL Number
MFCD00932428
PubChem ID
82146
Melting Point
220 - 225 °C
Appearance
White to orange to green powder to crystal
Conditions
Store at < -20 °C
General Information
Synonyms
Targretin
CAS Number
153559-49-0
Purity
≥ 96% (HPLC)
Molecular Formula
C24H28O2
Molecular Weight
348.49
MDL Number
MFCD00932428
PubChem ID
82146
Melting Point
220 - 225 °C
Appearance
White to orange to green powder to crystal
Conditions
Store at < -20 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Bexarotene is widely utilized in research focused on:

  • Cancer Treatment: Bexarotene is primarily used in oncology, particularly for treating cutaneous T-cell lymphoma (CTCL). Its ability to induce apoptosis in cancer cells makes it a valuable option for patients who have not responded to other therapies.
  • Neurodegenerative Disease Research: Researchers are exploring Bexarotene's potential in treating Alzheimer's disease. Studies suggest it may help clear amyloid plaques in the brain, offering hope for new therapeutic strategies.
  • Skin Care Products: The compound is being investigated for its use in dermatological formulations. Its retinoid-like properties can improve skin texture and reduce signs of aging, making it appealing for cosmetic applications.
  • Pharmaceutical Development: Bexarotene serves as a model compound in drug discovery, helping scientists understand the mechanisms of retinoid action and developing new retinoid-based therapies.
  • Environmental Research: Its effects on wildlife and ecosystems are being studied, particularly in relation to its potential impact on endocrine systems, which can inform regulatory policies and environmental safety assessments.

Citations