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Catalog Number:
02454
CAS Number:
71989-33-8
Fmoc-O-tert-butyl-L-serine
Purity:
≥ 99.5% (Chiral HPLC, HPLC)
Synonym(s):
Fmoc-L-Ser(tBu)-OH
Documents
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Product Information

Fmoc-O-tert-butyl-L-serine is a versatile amino acid derivative widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the field of medicinal chemistry and drug development. Its tert-butyl group enhances solubility and stability, facilitating smoother reactions and improving yields in complex synthetic pathways.

Researchers and industry professionals appreciate Fmoc-O-tert-butyl-L-serine for its role in the development of peptide-based therapeutics, where precise control over amino acid sequences is crucial. This compound is particularly advantageous in solid-phase peptide synthesis (SPPS), where its protective groups can be easily removed under mild conditions, allowing for the efficient assembly of peptides. Its unique properties make it a preferred choice for those looking to streamline their synthesis processes while achieving high purity and functionality in their final products.

Synonyms
Fmoc-L-Ser(tBu)-OH
CAS Number
71989-33-8
Purity
≥ 99.5% (Chiral HPLC, HPLC)
Molecular Formula
C22H25NO5
Molecular Weight
383.4
MDL Number
MFCD00037127
PubChem ID
3085671
Melting Point
125 - 140 °C
Appearance
White powder
Optical Rotation
[a]D20 = 25 ± 3 º (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Ser(tBu)-OH
CAS Number
71989-33-8
Purity
≥ 99.5% (Chiral HPLC, HPLC)
Molecular Formula
C22H25NO5
Molecular Weight
383.4
MDL Number
MFCD00037127
PubChem ID
3085671
Melting Point
125 - 140 °C
Appearance
White powder
Optical Rotation
[a]D20 = 25 ± 3 º (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-L-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group for the amino acid serine during peptide synthesis, allowing for the selective modification of other amino acids without affecting serine.
  • Drug Development: It plays a crucial role in the design of peptide-based therapeutics, particularly in the development of drugs targeting specific biological pathways.
  • Bioconjugation: Researchers use it to facilitate the attachment of biomolecules to surfaces or other molecules, enhancing the efficacy of diagnostics and therapeutics.
  • Protein Engineering: The compound is used in the modification of proteins to improve their stability and functionality, which is essential in various biotechnological applications.
  • Research in Neuroscience: It is applied in studies involving neurotransmitter systems, where modified peptides can help in understanding receptor interactions and signaling pathways.

Citations