Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
02448
CAS Number:
71989-31-6
Fmoc-L-proline
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Pro-OH, (S-Fmoc-pyrrolidine-2-carboxylic acid
Documents
$18.53 /5G
Pack Size Availability Price
Request Bulk Quote
Product Information

Fmoc-L-proline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers and professionals in the pharmaceutical and biotechnology sectors. Its unique structure enhances stability and solubility, facilitating the formation of complex peptides and proteins.

In addition to its role in peptide synthesis, Fmoc-L-proline has applications in the development of bioactive compounds and can be used in the design of peptide-based therapeutics. Its ability to introduce conformational rigidity into peptide chains makes it particularly valuable in the study of protein folding and interactions. Researchers appreciate its compatibility with various coupling reagents, which streamlines the synthesis process and improves yield. With its proven track record in enhancing peptide synthesis efficiency, Fmoc-L-proline stands out as a critical component for advancing research and development in the life sciences.

Synonyms
Fmoc-L-Pro-OH, (S-Fmoc-pyrrolidine-2-carboxylic acid
CAS Number
71989-31-6
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C20H19NO4
Molecular Weight
337.4
MDL Number
MFCD00037122
PubChem ID
100106
Melting Point
100 - 118 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -32 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Pro-OH, (S-Fmoc-pyrrolidine-2-carboxylic acid
CAS Number
71989-31-6
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C20H19NO4
Molecular Weight
337.4
MDL Number
MFCD00037122
PubChem ID
100106
Melting Point
100 - 118 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -32 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-proline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective formation of peptide bonds while preventing unwanted reactions. Its stability under various conditions makes it a preferred choice for chemists.
  • Drug Development: In pharmaceutical research, Fmoc-L-proline is used to create peptide-based drugs. Its ability to enhance the stability and bioavailability of therapeutic peptides is crucial in developing effective medications.
  • Bioconjugation: The compound is employed in bioconjugation processes to attach biomolecules to surfaces or other molecules. This application is vital in creating targeted drug delivery systems and diagnostic tools.
  • Protein Engineering: Researchers utilize Fmoc-L-proline in the design of modified proteins. Its unique structure allows for the incorporation of proline residues, which can influence protein folding and stability, leading to improved functionality.
  • Material Science: In the development of new materials, Fmoc-L-proline is used to create polymeric systems with specific properties. Its role in enhancing the mechanical and thermal properties of materials is beneficial in various industrial applications.

Citations