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Catalog Number:
04138
CAS Number:
205526-26-7
Fmoc-2-fluoro-L-phenylalanine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Phe(2-F)-OH, Fmoc-o-fluoro-L-Phe-OH, Fmoc-Phe(2-F)-OH
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Product Information

Fmoc-2-fluoro-L-phenylalanine is a valuable amino acid derivative widely utilized in peptide synthesis and medicinal chemistry. This compound features a unique fluorine atom, which enhances its bioactivity and selectivity in various applications. Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for easy incorporation into peptide chains, making it an essential building block for researchers focused on developing novel therapeutics and biologically active peptides. The presence of the fluorine atom can improve the pharmacokinetic properties of peptides, potentially leading to more effective drug candidates.

In addition to its role in peptide synthesis, Fmoc-2-fluoro-L-phenylalanine is also employed in the development of targeted therapies and diagnostic agents. Its unique properties make it suitable for applications in drug discovery, particularly in the design of inhibitors and modulators for various biological targets. Researchers value this compound for its ability to enhance the efficacy and specificity of peptide-based drugs, making it a crucial tool in the pharmaceutical and biotechnology industries.

Synonyms
Fmoc-L-Phe(2-F)-OH, Fmoc-o-fluoro-L-Phe-OH, Fmoc-Phe(2-F)-OH
CAS Number
205526-26-7
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H20FNO4
Molecular Weight
405.4
MDL Number
MFCD00672552
PubChem ID
2759190
Melting Point
120 - 124 °C
Appearance
White powder
Optical Rotation
[a]D20 = -45 ± 2 ° (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Phe(2-F)-OH, Fmoc-o-fluoro-L-Phe-OH, Fmoc-Phe(2-F)-OH
CAS Number
205526-26-7
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H20FNO4
Molecular Weight
405.4
MDL Number
MFCD00672552
PubChem ID
2759190
Melting Point
120 - 124 °C
Appearance
White powder
Optical Rotation
[a]D20 = -45 ± 2 ° (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2-fluoro-L-phenylalanine is widely utilized in research focused on

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of fluorinated amino acids which can enhance the properties of the resulting peptides.
  • Drug Development: Its unique structure makes it valuable in the design of novel pharmaceuticals, especially in targeting specific receptors or enzymes, which can lead to more effective treatments with fewer side effects.
  • Bioconjugation: The presence of the fluoro group allows for selective labeling and conjugation in biochemistry, facilitating the development of targeted therapies and diagnostic tools in medical research.
  • Research in Protein Engineering: This compound is used to study the effects of fluorinated amino acids on protein folding and stability, providing insights into protein design and function.
  • Analytical Chemistry: It serves as a useful standard in analytical methods for quantifying amino acids and peptides, improving accuracy in research and quality control in pharmaceutical manufacturing.

Citations