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Catalog Number:
04090
CAS Number:
198561-04-5
Fmoc-4-bromo-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Phe(4-Br)-OH, Fmoc-p-bromo-L-Phe-OH, Fmoc-Phe(4-Br)-OH
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Product Information

Fmoc-4-bromo-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a 4-bromophenyl group, enhancing its reactivity and allowing for the introduction of bromine into peptide sequences, which can be crucial for the development of novel therapeutics. The Fmoc (9-fluorenylmethoxycarbonyl) protecting group is particularly valued for its stability under basic conditions, making it an ideal choice for solid-phase peptide synthesis. Researchers appreciate its ability to facilitate the formation of complex peptide structures, which are essential in various fields, including medicinal chemistry and biochemistry.

In addition to its role in peptide synthesis, Fmoc-4-bromo-L-phenylalanine can be employed in the study of protein interactions and the development of biomaterials. Its unique properties allow for the exploration of structure-activity relationships in drug design, providing insights that can lead to the discovery of new pharmaceutical agents. This compound stands out for its ability to enhance the specificity and efficacy of peptide-based drugs, making it a valuable asset for researchers and industry professionals alike.

Synonyms
Fmoc-L-Phe(4-Br)-OH, Fmoc-p-bromo-L-Phe-OH, Fmoc-Phe(4-Br)-OH
CAS Number
198561-04-5
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20BrNO4
Molecular Weight
466.3
MDL Number
MFCD00273460
PubChem ID
4712549
Melting Point
204 - 210 °C (Lit.)
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -19 ± 2 º (C=1 in DMF) (Lit.)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(4-Br)-OH, Fmoc-p-bromo-L-Phe-OH, Fmoc-Phe(4-Br)-OH
CAS Number
198561-04-5
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20BrNO4
Molecular Weight
466.3
MDL Number
MFCD00273460
PubChem ID
4712549
Melting Point
204 - 210 °C (Lit.)
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -19 ± 2 º (C=1 in DMF) (Lit.)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-bromo-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as an important building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the incorporation of brominated phenylalanine into peptide chains.
  • Drug Development: Its unique properties make it valuable in the design of novel pharmaceuticals, especially in targeting specific biological pathways due to the presence of the bromine atom, which can enhance binding interactions.
  • Bioconjugation: The compound can be used in bioconjugation techniques, where it helps in attaching biomolecules to surfaces or other molecules, facilitating the development of targeted drug delivery systems.
  • Research in Protein Engineering: Researchers utilize this chemical to modify proteins, which can lead to improved stability and functionality, making it essential in the field of synthetic biology.
  • Fluorescent Labeling: Its structure allows for the incorporation of fluorescent tags in biomolecules, aiding in visualization and tracking in various biological assays.

Citations