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Catalog Number:
02575
CAS Number:
169243-86-1
Fmoc-4-fluoro-L-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Phe(4-F)-OH, Fmoc-p-fluoro-L-Phe-OH, Fmoc-Phe(4-F)-OH
Documents
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Product Information

Fmoc-4-fluoro-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique 4-fluorophenyl side chain enhances the compound's hydrophobicity and stability, making it an excellent choice for researchers focusing on the design of bioactive peptides and pharmaceuticals.

In addition to its role in peptide synthesis, Fmoc-4-fluoro-L-phenylalanine has shown potential in the development of novel therapeutic agents, particularly in the fields of oncology and neurology. Its ability to facilitate the incorporation of fluorinated amino acids into peptides allows for the exploration of new drug candidates with improved pharmacological properties. Researchers appreciate its compatibility with various coupling reagents and its effectiveness in generating high-purity peptides, making it a valuable tool in both academic and industrial laboratories.

Synonyms
Fmoc-L-Phe(4-F)-OH, Fmoc-p-fluoro-L-Phe-OH, Fmoc-Phe(4-F)-OH
CAS Number
169243-86-1
Purity
≥ 99% (HPLC)
Molecular Formula
C24H20FNO4
Molecular Weight
405.4
MDL Number
MFCD00191197
PubChem ID
6957972
Melting Point
175 - 195 °C
Appearance
White powder
Optical Rotation
[a]D20 = -37.5 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(4-F)-OH, Fmoc-p-fluoro-L-Phe-OH, Fmoc-Phe(4-F)-OH
CAS Number
169243-86-1
Purity
≥ 99% (HPLC)
Molecular Formula
C24H20FNO4
Molecular Weight
405.4
MDL Number
MFCD00191197
PubChem ID
6957972
Melting Point
175 - 195 °C
Appearance
White powder
Optical Rotation
[a]D20 = -37.5 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-fluoro-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is commonly used as a building block in solid-phase peptide synthesis, allowing researchers to create complex peptides with high purity and yield.
  • Drug Development: Its unique properties make it valuable in the pharmaceutical industry for designing novel therapeutics, particularly in targeting specific biological pathways.
  • Bioconjugation: Fmoc-4-fluoro-L-phenylalanine can be employed in bioconjugation processes, facilitating the attachment of peptides to various biomolecules for enhanced drug delivery systems.
  • Fluorescent Probes: The fluorine atom in its structure allows for the development of fluorescent probes, which are essential in imaging techniques and biological assays.
  • Research in Cancer Therapeutics: Its application in modifying peptide sequences is crucial for developing targeted therapies in oncology, offering potential advantages over traditional treatments.

Citations