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Catalog Number:
02440
CAS Number:
77284-32-3
Fmoc-L-norleucine
Purity:
≥ 98% (Assay)
Synonym(s):
Fmoc-L-Nle-OH, Fmoc-L-2-aminohexanoic acid
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Product Information

Fmoc-L-norleucine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which allows for selective deprotection during the synthesis process, making it an essential tool for researchers in the field of organic chemistry and biochemistry. Its unique structure not only enhances stability but also facilitates the formation of complex peptides, which are crucial in the development of pharmaceuticals and biologically active compounds.

In addition to its role in peptide synthesis, Fmoc-L-norleucine is recognized for its application in the production of peptide-based therapeutics, including those targeting cancer and other diseases. Its ability to mimic natural amino acids while providing enhanced solubility and reactivity makes it a preferred choice among researchers. The compound's compatibility with various coupling reagents and its ease of use in solid-phase peptide synthesis further underscore its importance in both academic and industrial settings.

Synonyms
Fmoc-L-Nle-OH, Fmoc-L-2-aminohexanoic acid
CAS Number
77284-32-3
Purity
≥ 98% (Assay)
Molecular Formula
C21H23NO4
Molecular Weight
353.42
MDL Number
MFCD00037537
PubChem ID
7269372
Melting Point
140 - 146 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -20 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Nle-OH, Fmoc-L-2-aminohexanoic acid
CAS Number
77284-32-3
Purity
≥ 98% (Assay)
Molecular Formula
C21H23NO4
Molecular Weight
353.42
MDL Number
MFCD00037537
PubChem ID
7269372
Melting Point
140 - 146 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -20 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-norleucine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: In pharmaceutical research, it is used to develop peptide-based drugs, offering potential therapeutic benefits due to its structural properties that enhance bioactivity.
  • Bioconjugation: Fmoc-L-norleucine is employed in bioconjugation techniques, enabling the attachment of biomolecules to surfaces or other molecules, which is crucial in the development of targeted drug delivery systems.
  • Protein Engineering: Researchers utilize this compound in protein engineering to modify proteins for improved stability and functionality, which is essential in various biotechnological applications.
  • Research in Neuroscience: It is also used in studies related to neuropeptides, contributing to the understanding of neurotransmitter functions and potential treatments for neurological disorders.

Citations