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Catalog Number:
33019
CAS Number:
438625-61-7
Mca-(Asn670,Leu671-Amyloid β/A4 Protein Precursor770667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt
Synonym(s):
Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2trifluoroacetate salt, Mca-(Asn670,Leu671)-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide
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$480.02 /1MG
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Product Information

The compound Mca-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770(667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate is a specialized peptide that plays a significant role in biomedical research, particularly in the study of neurodegenerative diseases such as Alzheimer's. This compound is recognized for its structural similarity to amyloid-beta peptides, making it an essential tool for researchers investigating amyloid plaque formation and the underlying mechanisms of amyloid-related pathologies. Its unique amino acid sequence and modifications, including the incorporation of dinitrophenyl (Dnp) and trifluoroacetate, enhance its stability and solubility, facilitating various experimental applications.

Researchers utilize this compound in assays to evaluate the efficacy of potential therapeutic agents targeting amyloid-beta aggregation. Additionally, it serves as a valuable reference standard in mass spectrometry and other analytical techniques aimed at characterizing amyloid peptides. The compound's specific modifications allow for improved detection and quantification, making it a preferred choice for laboratories focused on neurobiology and drug development. With its relevance in advancing our understanding of amyloid-related diseases, this peptide is an indispensable asset for professionals in the field.

Synonyms
Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2trifluoroacetate salt, Mca-(Asn670,Leu671)-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide
CAS Number
438625-61-7
Molecular Formula
C86H125N27O29·C2HF3O2
Molecular Weight
2115.09
MDL Number
MFCD31692288
Conditions
Store at ≤ -10 °C
General Information
Synonyms
Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2trifluoroacetate salt, Mca-(Asn670,Leu671)-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide
CAS Number
438625-61-7
Molecular Formula
C86H125N27O29·C2HF3O2
Molecular Weight
2115.09
MDL Number
MFCD31692288
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Mca-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770(667-676)-Lys(Dnp)-Arg-Arg amide trifluoroaceta is widely utilized in research focused on:

  • Alzheimer's Disease Research: This compound plays a crucial role in studying amyloid-beta peptides, which are implicated in Alzheimer's disease. Researchers use it to understand the formation and aggregation of amyloid plaques, aiding in the development of potential therapies.
  • Neurodegenerative Disorder Studies: It is valuable in exploring mechanisms of neurodegeneration beyond Alzheimer's, allowing scientists to investigate other related conditions and their pathophysiology.
  • Drug Development: Pharmaceutical companies leverage this compound in the screening of new drugs aimed at modulating amyloid-beta aggregation, providing a pathway for innovative treatments.
  • Biomarker Discovery: The compound assists in identifying biomarkers for early diagnosis of neurodegenerative diseases, enhancing the ability to detect these conditions before significant symptoms arise.
  • Protein Interaction Studies: It is used to study the interactions between amyloid-beta and other proteins, contributing to a deeper understanding of cellular processes and potential therapeutic targets.

Citations