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Catalog Number:
11639
CAS Number:
117106-20-4
Fmoc-N-methyl-O-tert-butyl-L-threonine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-N-Me-L-Thr(tBu)-OH
Documents
$65.40 /100MG
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Product Information

Fmoc-N-methyl-O-tert-butyl-L-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug discovery. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure, characterized by the tert-butyl ether and N-methyl substitution, enhances its stability and solubility, making it an ideal choice for researchers looking to streamline their synthetic processes.

In the pharmaceutical industry, Fmoc-N-methyl-O-tert-butyl-L-threonine is particularly valuable for the development of bioactive peptides and therapeutic agents. Its application extends to the creation of peptide libraries for high-throughput screening, allowing for the rapid identification of potential drug candidates. Additionally, this compound's favorable properties facilitate its use in solid-phase peptide synthesis, where efficiency and yield are paramount. Researchers can leverage its unique characteristics to optimize their workflows and achieve higher purity in their final products.

Synonyms
Fmoc-N-Me-L-Thr(tBu)-OH
CAS Number
117106-20-4
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H29NO5
Molecular Weight
411.5
MDL Number
MFCD02094431
PubChem ID
15601073
Appearance
White to off-white solid
Optical Rotation
[a]D20 = 14 ± 1 ° (C=1 in MeOH)
Conditions
Store at ≤ - 15 °C
General Information
Synonyms
Fmoc-N-Me-L-Thr(tBu)-OH
CAS Number
117106-20-4
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H29NO5
Molecular Weight
411.5
MDL Number
MFCD02094431
PubChem ID
15601073
Appearance
White to off-white solid
Optical Rotation
[a]D20 = 14 ± 1 ° (C=1 in MeOH)
Conditions
Store at ≤ - 15 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-N-methyl-O-tert-butyl-L-threonine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the efficient assembly of complex peptide sequences.
  • Drug Development: It is employed in the development of pharmaceutical compounds, particularly in creating peptide-based drugs that can target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The chemical is useful in bioconjugation processes, where it can be linked to biomolecules for the development of targeted drug delivery systems, improving the specificity of treatments.
  • Research in Protein Engineering: Researchers utilize this compound to modify proteins, enabling the study of protein interactions and functions, which is crucial in understanding various biological processes.
  • Development of Diagnostic Tools: It plays a role in creating diagnostic agents, particularly in assays that require specific peptide recognition, aiding in the early detection of diseases.

Citations