Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
02665
CAS Number:
112883-42-8
Fmoc-N-methyl-L-norleucine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-N-Me-L-Nle-OH, Fmoc-N-methyl-L-2-aminohexanoic acid
Documents
$64.90 /1G
Pack Size Availability Price
Request Bulk Quote
Product Information

Fmoc-N-methyl-L-norleucine is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure allows for enhanced stability and solubility, making it an ideal choice for researchers focused on developing complex peptide sequences. Fmoc-N-methyl-L-norleucine is particularly advantageous in solid-phase peptide synthesis (SPPS), where it contributes to the efficiency and yield of the final product.

In addition to its role in peptide synthesis, this compound is also explored in the development of pharmaceuticals and biologically active compounds, where its properties can lead to improved bioavailability and efficacy. Researchers appreciate its versatility and effectiveness, especially when compared to other amino acid derivatives. With its robust applications in both academic and industrial settings, Fmoc-N-methyl-L-norleucine stands out as a crucial tool for advancing peptide chemistry and drug discovery.

Synonyms
Fmoc-N-Me-L-Nle-OH, Fmoc-N-methyl-L-2-aminohexanoic acid
CAS Number
112883-42-8
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.4
MDL Number
MFCD00235878
PubChem ID
4259757
Melting Point
112 - 125 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -22 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-N-Me-L-Nle-OH, Fmoc-N-methyl-L-2-aminohexanoic acid
CAS Number
112883-42-8
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.4
MDL Number
MFCD00235878
PubChem ID
4259757
Melting Point
112 - 125 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -22 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-N-methyl-L-norleucine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: It plays a role in the design of peptide-based pharmaceuticals, where its unique structure can enhance the stability and bioactivity of therapeutic peptides.
  • Bioconjugation: Fmoc-N-methyl-L-norleucine is used in bioconjugation techniques, facilitating the attachment of peptides to various biomolecules, which is essential for developing targeted drug delivery systems.
  • Research in Protein Engineering: Researchers utilize this compound to modify proteins, enabling the exploration of structure-function relationships and the development of novel protein therapeutics.
  • Analytical Chemistry: It is employed in analytical methods to study peptide interactions and stability, providing insights that are crucial for both academic research and industrial applications.

Citations