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Catalog Number:
05350
CAS Number:
77128-72-4
Fmoc-O-methyl-L-tyrosine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Tyr(Me)-OH, Fmoc-p-methoxy-L-Phe-OH, Fmoc-Tyr(Me)-OH
Documents
$51.18 /1G
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Product Information

Fmoc-O-methyl-L-tyrosine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for creating complex peptides. Its unique structure, characterized by the methoxy group on the aromatic ring, enhances its solubility and stability, facilitating smoother reactions and higher yields in various synthetic pathways.

Researchers and industry professionals appreciate Fmoc-O-methyl-L-tyrosine for its application in the development of therapeutic peptides, particularly in the fields of oncology and neurology. Its ability to incorporate into peptide chains while maintaining biological activity makes it an attractive option for designing novel pharmaceuticals. Additionally, its compatibility with solid-phase peptide synthesis (SPPS) techniques streamlines the production of peptides, allowing for efficient and scalable synthesis. This compound stands out for its role in advancing peptide-based therapeutics, providing a reliable option for researchers aiming to innovate in drug design.

Synonyms
Fmoc-L-Tyr(Me)-OH, Fmoc-p-methoxy-L-Phe-OH, Fmoc-Tyr(Me)-OH
CAS Number
77128-72-4
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C25H23NO5
Molecular Weight
417.47
MDL Number
MFCD00153368
PubChem ID
6915697
Melting Point
155 - 165 ºC
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 8 ± 2 º (C=1 in EtOAc)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Tyr(Me)-OH, Fmoc-p-methoxy-L-Phe-OH, Fmoc-Tyr(Me)-OH
CAS Number
77128-72-4
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C25H23NO5
Molecular Weight
417.47
MDL Number
MFCD00153368
PubChem ID
6915697
Melting Point
155 - 165 ºC
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 8 ± 2 º (C=1 in EtOAc)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-methyl-L-tyrosine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is commonly used in solid-phase peptide synthesis, allowing for the efficient assembly of peptides with specific sequences. Its protective Fmoc group facilitates the stepwise addition of amino acids.
  • Drug Development: Researchers in pharmaceutical industries leverage Fmoc-O-methyl-L-tyrosine to create novel peptide-based drugs, enhancing therapeutic efficacy and specificity in targeting diseases.
  • Bioconjugation: This chemical is valuable in bioconjugation techniques, where it helps link peptides to various biomolecules, improving the delivery and effectiveness of therapeutic agents.
  • Research in Neuroscience: It plays a role in studying neurotransmitter systems, as tyrosine derivatives are precursors to important neurotransmitters, aiding in the understanding of brain function and disorders.
  • Protein Engineering: Fmoc-O-methyl-L-tyrosine is utilized in the design of modified proteins, allowing scientists to explore structure-function relationships and develop proteins with enhanced properties.

Citations