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Catalog Number:
02425
CAS Number:
71989-23-6
Fmoc-L-isoleucine
Purity:
≥ 99.7% (Chiral HPLC)
Synonym(s):
Fmoc-L-Ile-OH, Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid
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Product Information

Fmoc-L-isoleucine is a versatile amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is crucial for the selective protection of the amino group during the synthesis of peptides. Its unique structure not only enhances the stability of the amino acid during chemical reactions but also facilitates the efficient assembly of complex peptide chains. Researchers and professionals in the fields of biochemistry and medicinal chemistry often employ Fmoc-L-isoleucine in solid-phase peptide synthesis (SPPS), where its properties contribute to higher yields and purities of the final products.

Additionally, Fmoc-L-isoleucine is recognized for its role in the development of peptide-based therapeutics, including those targeting various diseases. Its ability to provide a stable and easily removable protecting group makes it a preferred choice for synthesizing bioactive peptides. The compound's application extends to the production of peptide libraries for drug discovery, enabling researchers to explore a wide range of biological activities. With its reliable performance and significant contributions to peptide chemistry, Fmoc-L-isoleucine stands out as an essential tool for professionals in the life sciences.

Synonyms
Fmoc-L-Ile-OH, Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid
CAS Number
71989-23-6
Purity
≥ 99.7% (Chiral HPLC)
Molecular Formula
C21H23NO4
Molecular Weight
353.4
MDL Number
MFCD00037125
PubChem ID
100103
Melting Point
140 - 155 ºC
Appearance
White or off-white powder
Optical Rotation
[a]D20 = -12 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Ile-OH, Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid
CAS Number
71989-23-6
Purity
≥ 99.7% (Chiral HPLC)
Molecular Formula
C21H23NO4
Molecular Weight
353.4
MDL Number
MFCD00037125
PubChem ID
100103
Melting Point
140 - 155 ºC
Appearance
White or off-white powder
Optical Rotation
[a]D20 = -12 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-isoleucine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures for studying protein interactions and functions.
  • Drug Development: In pharmaceutical research, it is used to develop peptide-based drugs, particularly in targeting specific diseases, due to its ability to enhance the stability and bioavailability of therapeutic agents.
  • Biotechnology: Fmoc-L-isoleucine plays a crucial role in the production of recombinant proteins, aiding in the development of biologics and vaccines by providing essential amino acids for protein folding and function.
  • Analytical Chemistry: It is utilized in various analytical techniques, such as mass spectrometry, to help identify and quantify peptides, making it invaluable for quality control in pharmaceutical manufacturing.
  • Research in Neuroscience: This compound is used in studies related to neurotransmitter synthesis and function, contributing to the understanding of neurological disorders and potential treatments.

Citations