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Catalog Number:
00713
CAS Number:
109425-51-6
Nα-Fmoc-Nim-trityl-L-histidine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-His(Trt)-OH
Documents
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Product Information

Na-Fmoc-Nim-trityl-L-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of complex peptides. Its trityl group enhances stability and solubility, making it an excellent choice for researchers focused on synthesizing histidine-containing peptides. The unique structure of Na-Fmoc-Nim-trityl-L-histidine not only facilitates the formation of peptide bonds but also improves the overall yield and purity of the final product.

In the pharmaceutical industry, this compound is particularly valuable for developing therapeutic peptides that target specific biological pathways. Its application extends to the synthesis of peptide-based drugs, where the incorporation of histidine can enhance bioactivity and stability. Researchers in biochemistry and medicinal chemistry will find Na-Fmoc-Nim-trityl-L-histidine indispensable for advancing their projects, thanks to its reliable performance and compatibility with various coupling reagents.

Synonyms
Fmoc-L-His(Trt)-OH
CAS Number
109425-51-6
Purity
≥ 99% (HPLC)
Molecular Formula
C40H33N3O4
Molecular Weight
619.7
MDL Number
MFCD00043332
PubChem ID
4072357
Appearance
White powder
Optical Rotation
[a]D20 = 86 ± 8 º (C=5 in CHCl3)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-His(Trt)-OH
CAS Number
109425-51-6
Purity
≥ 99% (HPLC)
Molecular Formula
C40H33N3O4
Molecular Weight
619.7
MDL Number
MFCD00043332
PubChem ID
4072357
Appearance
White powder
Optical Rotation
[a]D20 = 86 ± 8 º (C=5 in CHCl3)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-trityl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and functional peptides with specific sequences.
  • Drug Development: It plays a significant role in pharmaceutical research, particularly in the development of peptide-based drugs, due to its ability to enhance stability and bioavailability of therapeutic peptides.
  • Bioconjugation: The compound is used in bioconjugation techniques, where it helps to attach biomolecules to surfaces or other molecules, facilitating the development of targeted drug delivery systems.
  • Research in Cancer Therapy: Its applications extend to cancer research, where it is utilized in the design of peptide-based inhibitors that can selectively target cancer cells, improving treatment efficacy.
  • Protein Engineering: This chemical is valuable in protein engineering, aiding researchers in modifying proteins to enhance their function or stability, which is crucial for various biotechnological applications.

Citations