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Catalog Number:
03747
CAS Number:
147762-53-6
Fmoc-O-phospho-L-tyrosine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Tyr(H2PO3)-OH
Documents
$75.00 /250MG
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Product Information

Fmoc-O-phospho-L-tyrosine is a versatile phosphotyrosine derivative widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis of peptides, making it an essential building block for researchers in the fields of biochemistry and molecular biology. Its unique phosphonate group enhances the compound's solubility and reactivity, facilitating its incorporation into peptides that are crucial for studying protein interactions, signal transduction pathways, and enzyme activity.

Researchers and industry professionals can leverage Fmoc-O-phospho-L-tyrosine in the development of phosphopeptide libraries, which are instrumental in drug discovery and the design of targeted therapies. Its ability to mimic natural phosphotyrosine residues makes it particularly valuable for studying phosphorylation events in cellular signaling. Additionally, the compound's stability and compatibility with various coupling reagents further enhance its utility in synthetic applications, providing a reliable option for those looking to explore the complexities of protein function and regulation.

Synonyms
Fmoc-L-Tyr(H2PO3)-OH
CAS Number
147762-53-6
Purity
≥ 98% (HPLC)
Molecular Formula
C24H22NO8P
Molecular Weight
483.41
MDL Number
MFCD00235902
PubChem ID
23033088
Melting Point
138 - 172 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 6.5 ± 2 º (C=2 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Tyr(H2PO3)-OH
CAS Number
147762-53-6
Purity
≥ 98% (HPLC)
Molecular Formula
C24H22NO8P
Molecular Weight
483.41
MDL Number
MFCD00235902
PubChem ID
23033088
Melting Point
138 - 172 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 6.5 ± 2 º (C=2 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-phospho-L-tyrosine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of phosphorylated peptides, which are crucial for studying protein interactions and signaling pathways.
  • Drug Development: Its ability to mimic phosphorylated amino acids makes it valuable in the design of drugs targeting specific protein functions, particularly in cancer research.
  • Bioconjugation: Fmoc-O-phospho-L-tyrosine can be used to create conjugates with biomolecules, enhancing the delivery and efficacy of therapeutic agents.
  • Analytical Chemistry: Researchers utilize this compound in assays to detect and quantify phosphorylation states of proteins, aiding in the understanding of cellular processes.
  • Biotechnology: It plays a significant role in the development of biosensors that monitor cellular responses, providing insights into metabolic and signaling pathways.

Citations