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Catalog Number:
03815
CAS Number:
15160-31-3
Nα-Boc-L-tryptophan 4-nitrophenyl ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Boc-L-Trp-ONp
Documents
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Product Information

Na-Boc-L-tryptophan 4-nitrophenyl ester is a versatile compound widely utilized in peptide synthesis and medicinal chemistry. This derivative of tryptophan features a protective Boc (tert-butyloxycarbonyl) group, which enhances its stability and facilitates the selective functionalization of the amino acid. The presence of the 4-nitrophenyl ester moiety not only aids in the activation of the carboxylic acid but also allows for easy cleavage under mild conditions, making it an ideal choice for researchers looking to synthesize complex peptides or study tryptophan derivatives.

This compound is particularly valuable in the development of pharmaceuticals, where it can be employed in the design of novel therapeutic agents targeting neurological disorders, given tryptophan's role as a precursor to serotonin. Additionally, its application in bioconjugation strategies opens avenues for creating targeted drug delivery systems. With its unique properties, Na-Boc-L-tryptophan 4-nitrophenyl ester stands out as a crucial building block for researchers aiming to innovate in peptide-based therapies.

Synonyms
Boc-L-Trp-ONp
CAS Number
15160-31-3
Purity
≥ 98% (HPLC)
Molecular Formula
C22H23N3O6
Molecular Weight
425.4
MDL Number
MFCD00022757
PubChem ID
85810
Appearance
Yellow powder
Optical Rotation
[a]D20 = +3.5 ± 1 º (C=1 in EtOH)
Conditions
Store at 0-8°C
General Information
Synonyms
Boc-L-Trp-ONp
CAS Number
15160-31-3
Purity
≥ 98% (HPLC)
Molecular Formula
C22H23N3O6
Molecular Weight
425.4
MDL Number
MFCD00022757
PubChem ID
85810
Appearance
Yellow powder
Optical Rotation
[a]D20 = +3.5 ± 1 º (C=1 in EtOH)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Boc-L-tryptophan 4-nitrophenyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly those involving tryptophan. Its protective Boc group allows for selective reactions, making it easier to construct complex peptide sequences.
  • Drug Development: In pharmaceutical research, it is used to create derivatives that can enhance the bioavailability of drugs. The incorporation of tryptophan can improve the pharmacological properties of compounds, making them more effective.
  • Bioconjugation: It is applied in bioconjugation techniques, where it helps in attaching biomolecules to surfaces or other molecules. This is crucial in developing targeted drug delivery systems and diagnostic tools.
  • Research on Neurotransmitters: Given tryptophan's role as a precursor to serotonin, this compound is valuable in studies exploring neurotransmitter pathways and their implications in mental health and mood disorders.
  • Fluorescent Labeling: The nitrophenyl group can be utilized in fluorescent labeling applications, aiding in the visualization of biological processes in live cells, which is essential for cellular and molecular biology research.

Citations