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Catalog Number:
02459
CAS Number:
117872-75-0
Fmoc-O-benzyl-L-threonine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Thr(Bzl)-OH
Documents
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Product Information

Fmoc-O-benzyl-L-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for constructing complex peptides. Its unique structure, characterized by the presence of a benzyl group, enhances solubility and stability, facilitating smoother reactions and higher yields in various synthetic pathways. Researchers in pharmaceutical and biotechnological fields often leverage Fmoc-O-benzyl-L-threonine for its ability to improve the efficiency of solid-phase peptide synthesis, enabling the production of therapeutic peptides with enhanced bioactivity and specificity.

In addition to its applications in peptide synthesis, Fmoc-O-benzyl-L-threonine is also valuable in the development of novel biomaterials and drug delivery systems. Its compatibility with various coupling reagents and its ability to form stable linkages make it an attractive choice for researchers aiming to create innovative therapeutic agents. By incorporating this compound into their projects, professionals can enhance the efficacy and functionality of their peptide-based products, ultimately contributing to advancements in medical research and treatment options.

Synonyms
Fmoc-L-Thr(Bzl)-OH
CAS Number
117872-75-0
Purity
≥ 99% (HPLC)
Molecular Formula
C26H25NO5
Molecular Weight
431.5
MDL Number
MFCD00077073
Melting Point
118 - 120 °C
Appearance
White powder
Optical Rotation
[a]20D = 11 ± 2 ° (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Thr(Bzl)-OH
CAS Number
117872-75-0
Purity
≥ 99% (HPLC)
Molecular Formula
C26H25NO5
Molecular Weight
431.5
MDL Number
MFCD00077073
Melting Point
118 - 120 °C
Appearance
White powder
Optical Rotation
[a]20D = 11 ± 2 ° (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-benzyl-L-threonine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the efficient assembly of complex peptides while preventing unwanted reactions.
  • Drug Development: It is used in the design of peptide-based therapeutics, providing a versatile building block for creating bioactive compounds that can target specific biological pathways.
  • Bioconjugation: The compound facilitates the attachment of peptides to other molecules, such as drugs or imaging agents, enhancing their delivery and efficacy in therapeutic applications.
  • Research in Protein Engineering: Fmoc-O-benzyl-L-threonine is valuable in the modification of proteins, allowing researchers to study structure-function relationships and improve protein stability.
  • Analytical Chemistry: It is employed in the development of analytical methods for characterizing peptides and proteins, aiding in quality control and research applications.

Citations