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Catalog Number:
08085
CAS Number:
158171-15-4
Fmoc-O-phospho-L-serine
Purity:
≥ 98% (Assay)
Synonym(s):
Fmoc-L-Ser(H2PO3)-OH
Documents
$140.00 /250MG
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Product Information

Fmoc-O-phospho-L-serine is a versatile phosphoserine derivative widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which facilitates the selective incorporation of phosphoserine into peptides while maintaining stability during synthesis. Its unique phosphonate group enhances its reactivity and solubility, making it an ideal choice for researchers focused on developing phosphopeptides that mimic biological signaling pathways.

In the realm of drug discovery and development, Fmoc-O-phospho-L-serine plays a crucial role in studying protein phosphorylation and its implications in various diseases, including cancer and neurodegenerative disorders. By enabling the synthesis of phosphopeptides that can interact with specific proteins, this compound aids in elucidating the mechanisms of action of therapeutic agents. Its application extends to the production of biomaterials and nanotechnology, where phosphoserine derivatives are used to create functionalized surfaces for biosensors and drug delivery systems.

Synonyms
Fmoc-L-Ser(H2PO3)-OH
CAS Number
158171-15-4
Purity
≥ 98% (Assay)
Molecular Formula
C18H18NO8P
Molecular Weight
407.32
MDL Number
MFCD00672324
PubChem ID
74765269
Appearance
White solid
Optical Rotation
[a]D20 = 4.5 ± 1 ° (C=1 in DMF)D25 = 4 ± 2 ° (C=1 in Methanol)
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Fmoc-L-Ser(H2PO3)-OH
CAS Number
158171-15-4
Purity
≥ 98% (Assay)
Molecular Formula
C18H18NO8P
Molecular Weight
407.32
MDL Number
MFCD00672324
PubChem ID
74765269
Appearance
White solid
Optical Rotation
[a]D20 = 4.5 ± 1 ° (C=1 in DMF)D25 = 4 ± 2 ° (C=1 in Methanol)
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-phospho-L-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of phosphopeptides, which are essential for studying protein phosphorylation and signaling pathways.
  • Drug Development: It is used in the development of pharmaceuticals that target specific protein interactions, particularly in cancer research, where phosphorylation plays a critical role in tumor progression.
  • Bioconjugation: Fmoc-O-phospho-L-serine can be employed in bioconjugation techniques to attach biomolecules to surfaces or other molecules, enhancing the functionality of drug delivery systems.
  • Analytical Chemistry: Researchers utilize this compound in various assays to detect and quantify phosphorylated proteins, aiding in the understanding of cellular processes.
  • Biotechnology: It is applied in the production of modified proteins for therapeutic use, providing advantages in stability and activity compared to non-phosphorylated counterparts.

Citations