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Catalog Number:
05764
CAS Number:
146346-81-8
Fmoc-O-tert-butyldimethylsilyl-L-serine
Purity:
≥ 99.9% (Chiral HPLC)
Synonym(s):
Fmoc-L-Ser(Bsi)-OH
Documents
$72.31 /250MG
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Product Information

Fmoc-O-tert-butyldimethylsilyl-L-serine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which is crucial for the selective protection of the amino group during the synthesis of peptides. Its tert-butyldimethylsilyl (TBDMS) group provides additional stability and protection for the hydroxyl group, making it an ideal choice for complex synthetic pathways. Researchers and industry professionals appreciate its ability to facilitate the synthesis of peptides with enhanced solubility and stability, which is essential for various applications in pharmaceuticals and biotechnology.

In practical applications, Fmoc-O-tert-butyldimethylsilyl-L-serine is particularly valuable in the development of therapeutic peptides and biologically active compounds. Its unique protective groups allow for efficient coupling reactions and deprotection steps, streamlining the synthesis process. This compound is also beneficial in the creation of peptide libraries for drug discovery, enabling researchers to explore a wide range of bioactive peptides. With its robust performance and reliability, Fmoc-O-tert-butyldimethylsilyl-L-serine stands out as a preferred choice for professionals seeking high-quality reagents in peptide chemistry.

Synonyms
Fmoc-L-Ser(Bsi)-OH
CAS Number
146346-81-8
Purity
≥ 99.9% (Chiral HPLC)
Molecular Formula
C24H31NO5Si
Molecular Weight
441.6
MDL Number
MFCD02092931
PubChem ID
51003675
Melting Point
107 - 112 °C
Appearance
White powder
Optical Rotation
[a]D20 = +19 ± 3º (C=2 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Ser(Bsi)-OH
CAS Number
146346-81-8
Purity
≥ 99.9% (Chiral HPLC)
Molecular Formula
C24H31NO5Si
Molecular Weight
441.6
MDL Number
MFCD02092931
PubChem ID
51003675
Melting Point
107 - 112 °C
Appearance
White powder
Optical Rotation
[a]D20 = +19 ± 3º (C=2 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyldimethylsilyl-L-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for selective reactions without interfering with other functional groups. Its stability under various conditions makes it a preferred choice for chemists.
  • Drug Development: In pharmaceutical research, it aids in the design of peptide-based drugs, enhancing the bioavailability and stability of therapeutic agents. This is crucial for developing effective treatments.
  • Bioconjugation: It is used in bioconjugation processes to attach biomolecules to surfaces or other molecules, facilitating the creation of targeted drug delivery systems and diagnostic tools.
  • Protein Engineering: Researchers utilize this compound in modifying proteins to study their structure and function, which is essential for understanding biological processes and developing new biotechnologies.
  • Analytical Chemistry: It plays a role in analytical techniques, such as mass spectrometry, where it helps in the derivatization of amino acids and peptides, improving detection and quantification.

Citations