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Catalog Number:
03738
CAS Number:
116861-26-8
Fmoc-D-serine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Ser-OH, Fmoc-D-β-Hydroxyalanine, (R-Fmoc-2-amino-3-hydroxypropionic acid
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Product Information

Fmoc-D-serine is a versatile amino acid derivative widely utilized in peptide synthesis and research applications. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is crucial for the selective protection of the amino group during the synthesis of peptides. Its unique structure allows for efficient coupling reactions, making it an essential building block in the development of bioactive peptides and pharmaceuticals. Researchers appreciate Fmoc-D-serine for its stability and compatibility with various coupling reagents, enabling streamlined synthesis processes.

In addition to its role in peptide synthesis, Fmoc-D-serine has potential applications in the development of therapeutic agents, particularly in the fields of drug discovery and development. Its ability to facilitate the incorporation of D-amino acids into peptides can lead to enhanced biological activity and stability. This compound is particularly valuable in the design of peptidomimetics and other innovative biomolecules, making it a preferred choice for chemists and researchers focused on advancing pharmaceutical science.

Synonyms
Fmoc-D-Ser-OH, Fmoc-D-β-Hydroxyalanine, (R-Fmoc-2-amino-3-hydroxypropionic acid
CAS Number
116861-26-8
Purity
≥ 98% (HPLC)
Molecular Formula
C18H17NO5
Molecular Weight
327.3
MDL Number
MFCD00077068
PubChem ID
3297381
Melting Point
96 - 101 °C
Appearance
White to off-white powder
Optical Rotation
[a]20D = -14 ± 1 º (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Ser-OH, Fmoc-D-β-Hydroxyalanine, (R-Fmoc-2-amino-3-hydroxypropionic acid
CAS Number
116861-26-8
Purity
≥ 98% (HPLC)
Molecular Formula
C18H17NO5
Molecular Weight
327.3
MDL Number
MFCD00077068
PubChem ID
3297381
Melting Point
96 - 101 °C
Appearance
White to off-white powder
Optical Rotation
[a]20D = -14 ± 1 º (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-serine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective modification of amino acids without interfering with other functional groups.
  • Drug Development: Its role in synthesizing bioactive peptides makes it valuable in pharmaceutical research, particularly in developing new therapeutics targeting various diseases.
  • Bioconjugation: Fmoc-D-serine can be used in bioconjugation processes, facilitating the attachment of biomolecules to surfaces or other molecules, enhancing drug delivery systems.
  • Protein Engineering: Researchers leverage its properties to modify proteins, improving their stability and functionality, which is crucial in biotechnology applications.
  • Diagnostics: This compound can be incorporated into diagnostic assays, aiding in the detection of specific biomolecules, thereby enhancing the sensitivity and specificity of tests.

Citations