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Catalog Number:
05761
CAS Number:
71989-32-7
Fmoc-L-proline 4-nitrophenyl ester
Purity:
≥ 98% (TLC)
Synonym(s):
Fmoc-L-proline 4-nitrophenyl ester
Documents
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Product Information

Fmoc-L-proline 4-nitrophenyl ester is a versatile compound widely utilized in peptide synthesis and drug development. This derivative of proline features a protective Fmoc group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. The 4-nitrophenyl ester moiety enhances the compound's reactivity, making it an excellent choice for coupling reactions in the formation of complex peptides. Researchers appreciate its ability to provide high yields and purity in synthetic processes, which is crucial for the development of therapeutic peptides and biologically active compounds.

In addition to its role in peptide synthesis, Fmoc-L-proline 4-nitrophenyl ester is also valuable in the study of protein interactions and structure-function relationships. Its unique properties allow for the exploration of proline's role in protein folding and stability. This compound is particularly beneficial for researchers focused on drug design and biomolecular research, as it enables the creation of tailored peptides with specific biological activities. With its reliable performance and broad applicability, Fmoc-L-proline 4-nitrophenyl ester stands out as a key reagent in modern chemical biology.

Synonyms
Fmoc-L-proline 4-nitrophenyl ester
CAS Number
71989-32-7
Purity
≥ 98% (TLC)
Molecular Formula
C26H22N2O6
Molecular Weight
458.47
MDL Number
MFCD00038532
PubChem ID
138113654
Melting Point
116-120º C
Appearance
Light yellow powder
Optical Rotation
-65.50º ± 1º (c=1% in DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-L-proline 4-nitrophenyl ester
CAS Number
71989-32-7
Purity
≥ 98% (TLC)
Molecular Formula
C26H22N2O6
Molecular Weight
458.47
MDL Number
MFCD00038532
PubChem ID
138113654
Melting Point
116-120º C
Appearance
Light yellow powder
Optical Rotation
-65.50º ± 1º (c=1% in DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-proline 4-nitrophenyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for selective reactions without interfering with other functional groups. Its stability under various conditions makes it a preferred choice for chemists.
  • Drug Development: In pharmaceutical research, it aids in the design of new drugs by facilitating the formation of complex peptide structures, which can lead to more effective therapeutic agents.
  • Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, enhancing the functionality of biosensors and drug delivery systems.
  • Research in Protein Engineering: It plays a crucial role in modifying proteins to study their structure and function, providing insights that are essential for developing new biotechnological applications.
  • Analytical Chemistry: Fmoc-L-proline 4-nitrophenyl ester is utilized in analytical methods to improve the detection and quantification of amino acids and peptides, offering higher sensitivity and specificity compared to traditional methods.

Citations