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Catalog Number:
04446
CAS Number:
184719-80-0
D-Proline tert-butyl ester hydrochloride
Purity:
≥ 99% (HPLC)
Synonym(s):
D-Pro-OtBu·HCl, (R-Pyrrolidine-2-carboxylic acid tert-butyl esterhydrochloride
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Product Information

D-Proline tert-butyl ester hydrochloride is a versatile compound widely utilized in the synthesis of peptides and other bioactive molecules. This derivative of proline offers enhanced solubility and stability, making it an ideal choice for researchers in medicinal chemistry and pharmaceutical development. Its unique structure allows for the incorporation of proline into various peptide sequences, which is crucial for the design of therapeutics targeting specific biological pathways.

In addition to its applications in peptide synthesis, D-Proline tert-butyl ester hydrochloride serves as a valuable building block in the development of chiral catalysts and ligands, facilitating asymmetric synthesis in organic chemistry. Its ability to improve reaction yields and selectivity positions it as a preferred reagent among chemists. With its favorable properties and practical applications, this compound is essential for advancing research and innovation in drug discovery and development.

Synonyms
D-Pro-OtBu·HCl, (R-Pyrrolidine-2-carboxylic acid tert-butyl esterhydrochloride
CAS Number
184719-80-0
Purity
≥ 99% (HPLC)
Molecular Formula
C9H17NO2·HCl
Molecular Weight
207.7
MDL Number
MFCD00153460
PubChem ID
22409048
Melting Point
107-113 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +30 ± 2º (C=1 in H2O)
Conditions
Store at 0-8 °C
General Information
Synonyms
D-Pro-OtBu·HCl, (R-Pyrrolidine-2-carboxylic acid tert-butyl esterhydrochloride
CAS Number
184719-80-0
Purity
≥ 99% (HPLC)
Molecular Formula
C9H17NO2·HCl
Molecular Weight
207.7
MDL Number
MFCD00153460
PubChem ID
22409048
Melting Point
107-113 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +30 ± 2º (C=1 in H2O)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

D-Proline tert-butyl ester hydrochloride is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in creating cyclic peptides that are essential in drug development.
  • Chiral Auxiliary: It acts as a chiral auxiliary in asymmetric synthesis, helping chemists produce enantiomerically pure compounds, which are crucial in pharmaceuticals.
  • Biochemical Research: Researchers use it to study protein folding and stability, providing insights into diseases related to protein misfolding.
  • Drug Development: Its role in modifying drug structures enhances bioavailability and efficacy, making it a key player in the pharmaceutical industry.
  • Material Science: The compound is explored in the development of novel materials, including polymers that exhibit unique properties for various applications.

Citations