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Catalog Number:
03130
CAS Number:
2133-40-6
L-Proline methyl ester hydrochloride
Purity:
≥ 98% (HPLC)
Synonym(s):
L-Pro-OMe·HCl, (S)-Pyrrolidine-2-carboxylic acid methyl esterhydrochloride
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Product Information

L-Proline methyl ester hydrochloride is a versatile compound widely utilized in the synthesis of various pharmaceuticals and agrochemicals. This derivative of proline serves as an essential building block in the development of peptide-based drugs, particularly in the fields of medicinal chemistry and biochemistry. Its unique structure allows for the introduction of proline residues in peptide sequences, enhancing the stability and bioactivity of therapeutic agents. Additionally, L-Proline methyl ester hydrochloride is employed in the preparation of chiral catalysts and ligands, which are crucial in asymmetric synthesis processes, providing researchers with a reliable tool for producing enantiomerically pure compounds.

The compound's solubility in water and organic solvents makes it an ideal candidate for various applications, including drug formulation and chemical research. Its ability to act as a protective group for carboxylic acids further expands its utility in organic synthesis. Researchers and industry professionals can leverage L-Proline methyl ester hydrochloride for innovative applications in drug discovery and development, making it a valuable addition to any chemical toolkit.

Synonyms
L-Pro-OMe·HCl, (S)-Pyrrolidine-2-carboxylic acid methyl esterhydrochloride
CAS Number
2133-40-6
Purity
≥ 98% (HPLC)
Molecular Formula
C6H11NO2·HCl
Molecular Weight
165.6
MDL Number
MFCD00012708
PubChem ID
12223519
Appearance
White crystalline powder/low melting solid
Optical Rotation
[a]D20 = -31 ± 4 ° (C = 0.5 in H2O)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
L-Pro-OMe·HCl, (S)-Pyrrolidine-2-carboxylic acid methyl esterhydrochloride
CAS Number
2133-40-6
Purity
≥ 98% (HPLC)
Molecular Formula
C6H11NO2·HCl
Molecular Weight
165.6
MDL Number
MFCD00012708
PubChem ID
12223519
Appearance
White crystalline powder/low melting solid
Optical Rotation
[a]D20 = -31 ± 4 ° (C = 0.5 in H2O)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

L-Proline methyl ester hydrochloride is widely utilized in research focused on:

  • Synthesis of Pharmaceuticals: This compound serves as an important intermediate in the synthesis of various pharmaceutical agents, particularly in the development of drugs targeting neurological disorders.
  • Peptide Synthesis: It is commonly used in the synthesis of peptides, enhancing the efficiency of coupling reactions due to its ability to stabilize reactive intermediates.
  • Chiral Catalysis: The compound acts as a chiral auxiliary in asymmetric synthesis, providing a means to produce enantiomerically pure compounds, which is crucial in the production of many drugs.
  • Biochemical Research: Researchers utilize it to study the role of proline derivatives in biological systems, including their effects on protein folding and stability.
  • Food Industry Applications: It can be used as a flavoring agent or food additive, contributing to the enhancement of taste profiles in various food products.

Citations