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Catalog Number:
02905
CAS Number:
16652-71-4
L-Proline benzyl ester hydrochloride
Purity:
≥ 98% (HPLC)
Synonym(s):
L-Pro-OBzl·HCl, (S)-Pyrrolidine-2-carboxylic acid benzyl esterhydrochloride
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Product Information

L-Proline benzyl ester hydrochloride is a versatile compound widely utilized in the fields of organic synthesis and pharmaceutical research. This compound serves as an important building block in the synthesis of various bioactive molecules, particularly in the development of peptide-based drugs. Its unique structure allows for the introduction of proline residues into peptides, enhancing their stability and biological activity. Researchers appreciate its ability to facilitate the formation of cyclic peptides, which are known for their improved binding affinity and selectivity in biological systems.

In addition to its applications in drug discovery, L-Proline benzyl ester hydrochloride is also employed in the synthesis of chiral intermediates, making it invaluable in asymmetric synthesis processes. Its high purity and stability make it a preferred choice for researchers seeking reliable reagents for complex chemical reactions. With its potential to streamline synthetic pathways and improve the efficacy of pharmaceutical compounds, this ester hydrochloride is an essential tool for chemists and industry professionals alike.

Synonyms
L-Pro-OBzl·HCl, (S)-Pyrrolidine-2-carboxylic acid benzyl esterhydrochloride
CAS Number
16652-71-4
Purity
≥ 98% (HPLC)
Molecular Formula
C12H15NO2·HCl
Molecular Weight
241.7
MDL Number
MFCD00039002
PubChem ID
3084256
Melting Point
138 - 152 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -44 ± 2 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
L-Pro-OBzl·HCl, (S)-Pyrrolidine-2-carboxylic acid benzyl esterhydrochloride
CAS Number
16652-71-4
Purity
≥ 98% (HPLC)
Molecular Formula
C12H15NO2·HCl
Molecular Weight
241.7
MDL Number
MFCD00039002
PubChem ID
3084256
Melting Point
138 - 152 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -44 ± 2 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

L-Proline benzyl ester hydrochloride is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in creating cyclic peptides that have enhanced stability and bioactivity.
  • Pharmaceutical Development: It is used in the development of various pharmaceuticals, especially those targeting neurological disorders, due to its ability to cross the blood-brain barrier effectively.
  • Chiral Catalysis: The compound acts as a chiral catalyst in asymmetric synthesis, allowing for the production of enantiomerically pure compounds, which is crucial in drug development.
  • Bioconjugation: It plays a role in bioconjugation processes, linking biomolecules to drugs or imaging agents, enhancing the specificity and efficacy of therapeutic agents.
  • Research in Organic Chemistry: Researchers leverage its unique properties to explore new synthetic pathways and reactions, contributing to advancements in organic chemistry methodologies.

Citations