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Catalog Number:
02449
CAS Number:
86060-90-4
Fmoc-L-proline pentafluorophenyl ester
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Pro-OPfp, (S-Fmoc-pyrrolidine-2-carboxylic acid pentafluorophenylester
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Product Information

Fmoc-L-proline pentafluorophenyl ester is a versatile and highly valuable compound in the field of peptide synthesis and medicinal chemistry. This compound serves as a protective group for amino acids, particularly in the solid-phase peptide synthesis process, where it enhances the stability and solubility of the intermediates. Its unique structure, featuring a fluorenylmethoxycarbonyl (Fmoc) group, allows for easy removal under mild conditions, making it an ideal choice for researchers looking to streamline their synthesis workflows.

Moreover, the incorporation of the pentafluorophenyl moiety not only increases the lipophilicity of the compound but also improves its reactivity, making it suitable for a variety of applications in drug development and bioconjugation. Researchers have successfully utilized Fmoc-L-proline pentafluorophenyl ester in the synthesis of bioactive peptides and complex natural products, showcasing its potential in developing therapeutics with enhanced efficacy. Its ability to facilitate the formation of peptide bonds while maintaining the integrity of the amino acid structure positions it as a crucial tool for professionals in the pharmaceutical and biotechnology sectors.

Synonyms
Fmoc-L-Pro-OPfp, (S-Fmoc-pyrrolidine-2-carboxylic acid pentafluorophenylester
CAS Number
86060-90-4
Purity
≥ 99% (HPLC)
Molecular Formula
C26H18NO4F5
Molecular Weight
503.4
MDL Number
MFCD00065672
PubChem ID
3369501
Melting Point
122-130 ºC
Appearance
White powder
Optical Rotation
[a]D20 = -57 to -64º (c=1% in CHCl3)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Pro-OPfp, (S-Fmoc-pyrrolidine-2-carboxylic acid pentafluorophenylester
CAS Number
86060-90-4
Purity
≥ 99% (HPLC)
Molecular Formula
C26H18NO4F5
Molecular Weight
503.4
MDL Number
MFCD00065672
PubChem ID
3369501
Melting Point
122-130 ºC
Appearance
White powder
Optical Rotation
[a]D20 = -57 to -64º (c=1% in CHCl3)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-proline pentafluorophenyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the introduction of proline residues with high efficiency and specificity.
  • Drug Development: It is used in the design of pharmaceutical compounds, particularly in creating peptide-based drugs that target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The ester can be employed in bioconjugation techniques, linking biomolecules to surfaces or other molecules, which is crucial in developing biosensors and drug delivery systems.
  • Research in Protein Engineering: It aids researchers in modifying proteins to study structure-function relationships, providing insights into protein behavior and interactions.
  • Fluorinated Compound Applications: The presence of fluorine enhances the stability and bioavailability of compounds, making it valuable in various applications in medicinal chemistry.

Citations