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Catalog Number:
02238
CAS Number:
6404-31-5
Z-D-proline
Purity:
≥ 98% (HPLC)
Synonym(s):
Z-D-Pro-OH, (R-Z-pyrrolidine-2-carboxylic acid
Documents
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Product Information

Z-D-proline is a valuable amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound, known for its unique cyclic structure, offers enhanced stability and specificity in various applications, making it an essential building block for the development of bioactive peptides. Its ability to induce specific conformations in peptide chains allows researchers to design compounds with improved biological activity, particularly in drug discovery and development. Z-D-proline is also recognized for its role in stabilizing protein structures, which is crucial in the formulation of therapeutic proteins and enzymes.

In addition to its applications in pharmaceuticals, Z-D-proline serves as a chiral auxiliary in asymmetric synthesis, facilitating the production of enantiomerically pure compounds. This characteristic is particularly beneficial in the synthesis of complex organic molecules, where chirality plays a critical role in determining biological activity. Researchers and industry professionals can leverage Z-D-proline's unique properties to enhance the efficacy and safety profiles of their products, making it a key component in advancing medicinal chemistry and biochemistry.

Synonyms
Z-D-Pro-OH, (R-Z-pyrrolidine-2-carboxylic acid
CAS Number
6404-31-5
Purity
≥ 98% (HPLC)
Molecular Formula
C13H15NO4
Molecular Weight
249.27
MDL Number
MFCD00063228
PubChem ID
232388
Melting Point
72-80 °C
Appearance
White to off-white crystalline powder
Optical Rotation
[a]D = +39º to +43º (C=2 in EtOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Z-D-Pro-OH, (R-Z-pyrrolidine-2-carboxylic acid
CAS Number
6404-31-5
Purity
≥ 98% (HPLC)
Molecular Formula
C13H15NO4
Molecular Weight
249.27
MDL Number
MFCD00063228
PubChem ID
232388
Melting Point
72-80 °C
Appearance
White to off-white crystalline powder
Optical Rotation
[a]D = +39º to +43º (C=2 in EtOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Z-D-proline is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a valuable building block in the synthesis of peptides, particularly in the creation of cyclic peptides, which are important in drug development and therapeutic applications.
  • Drug Design: Its unique structure allows for the development of novel pharmaceuticals, especially in the treatment of neurological disorders, by enhancing the stability and bioavailability of drug candidates.
  • Protein Engineering: Z-D-proline is used to introduce conformational constraints in proteins, aiding researchers in studying protein folding and stability, which is crucial for understanding diseases.
  • Biotechnology: In the field of biotechnology, it serves as a chiral auxiliary in asymmetric synthesis, allowing for the production of enantiomerically pure compounds, which are essential in many applications.
  • Research in Metabolism: It is employed in metabolic studies to understand proline metabolism and its implications in various physiological processes, providing insights into metabolic disorders.

Citations