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Catalog Number:
01699
CAS Number:
5497-76-7
L-Proline tert-butyl ester hydrochloride
Purity:
97.5 - 102.5% (Assay by titration)
Synonym(s):
L-Pro-OtBu·HCl, (S-Pyrrolidine-2-carboxylic acid tert-butyl esterhydrochloride
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Product Information

L-Proline tert-butyl ester hydrochloride is a versatile compound widely utilized in the synthesis of peptides and pharmaceuticals. This derivative of proline offers enhanced solubility and stability, making it an ideal choice for researchers and industry professionals engaged in organic synthesis and drug development. Its unique structure allows for easier incorporation into various chemical reactions, particularly in the formation of peptide bonds, which are crucial in the development of biologically active compounds.

In addition to its applications in peptide synthesis, L-Proline tert-butyl ester hydrochloride serves as a valuable chiral auxiliary in asymmetric synthesis, facilitating the production of enantiomerically pure compounds. This characteristic is particularly beneficial in the pharmaceutical industry, where the efficacy and safety of drugs can depend on their stereochemistry. With its favorable properties and practical applications, this compound is an essential tool for chemists aiming to innovate and optimize their synthetic pathways.

Synonyms
L-Pro-OtBu·HCl, (S-Pyrrolidine-2-carboxylic acid tert-butyl esterhydrochloride
CAS Number
5497-76-7
Purity
97.5 - 102.5% (Assay by titration)
Molecular Formula
C9H17NO2·HCl
Molecular Weight
207.7
MDL Number
MFCD00153459
PubChem ID
22409048
Melting Point
91 - 110 °C
Appearance
White crystalline powder
Optical Rotation
[a]20D = -33 ± 2.5 ° (C=2 in EtOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
L-Pro-OtBu·HCl, (S-Pyrrolidine-2-carboxylic acid tert-butyl esterhydrochloride
CAS Number
5497-76-7
Purity
97.5 - 102.5% (Assay by titration)
Molecular Formula
C9H17NO2·HCl
Molecular Weight
207.7
MDL Number
MFCD00153459
PubChem ID
22409048
Melting Point
91 - 110 °C
Appearance
White crystalline powder
Optical Rotation
[a]20D = -33 ± 2.5 ° (C=2 in EtOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

L-Proline tert-butyl ester hydrochloride is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, which are crucial in drug development and biochemistry.
  • Pharmaceutical Applications: It is used in the formulation of various pharmaceuticals, particularly in creating proline derivatives that can enhance drug efficacy.
  • Biochemical Research: Researchers employ this compound to study protein folding and enzyme activity, providing insights into biological processes and disease mechanisms.
  • Chiral Catalysis: Its chiral nature makes it an excellent candidate in asymmetric synthesis, allowing for the production of enantiomerically pure compounds, which are essential in the pharmaceutical industry.
  • Cosmetic Formulations: The compound is also explored in cosmetic chemistry for its potential to improve skin hydration and elasticity, making it a beneficial ingredient in skincare products.

Citations