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Catalog Number:
02446
CAS Number:
101214-43-1
Fmoc-L-phenylalanine N-hydroxysuccinimide ester
Purity:
≥ 99.5% (HPLC)
Synonym(s):
Fmoc-L-Phe-OSu
Documents
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Product Information

Fmoc-L-phenylalanine N-hydroxysuccinimide ester is a versatile compound widely utilized in peptide synthesis and drug development. This compound serves as a key building block in the creation of peptide chains, particularly in solid-phase peptide synthesis (SPPS). Its unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for selective deprotection, facilitating the introduction of various amino acids in a controlled manner. The N-hydroxysuccinimide ester functionality enhances its reactivity, making it an ideal choice for coupling reactions with amines, which is essential in the synthesis of complex peptides and bioactive molecules.

Researchers and industry professionals benefit from the compound's ability to streamline the synthesis process, reduce side reactions, and improve overall yields. Its application extends to pharmaceutical research, where it plays a crucial role in developing therapeutic peptides and proteins. With its favorable properties, Fmoc-L-phenylalanine N-hydroxysuccinimide ester stands out as a reliable choice for those looking to enhance their peptide synthesis workflows and achieve high-quality results.

Synonyms
Fmoc-L-Phe-OSu
CAS Number
101214-43-1
Purity
≥ 99.5% (HPLC)
Molecular Formula
C28H24N2O6
Molecular Weight
484.5
MDL Number
MFCD00062204
Melting Point
157-165 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -64 ± 2º (C=1 in DMF)
Conditions
Store at ≤ -15C
General Information
Synonyms
Fmoc-L-Phe-OSu
CAS Number
101214-43-1
Purity
≥ 99.5% (HPLC)
Molecular Formula
C28H24N2O6
Molecular Weight
484.5
MDL Number
MFCD00062204
Melting Point
157-165 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -64 ± 2º (C=1 in DMF)
Conditions
Store at ≤ -15C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-phenylalanine N-hydroxysuccinimide ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the introduction of phenylalanine residues. Its stability and ease of use make it a preferred choice for researchers in biochemistry and molecular biology.
  • Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. Its ability to facilitate the formation of stable peptide bonds enhances the efficiency of drug design processes.
  • Bioconjugation: The compound is effective in bioconjugation applications, where it helps to attach biomolecules to surfaces or other molecules, improving the delivery and efficacy of therapeutic agents.
  • Protein Engineering: Researchers utilize this ester in protein engineering to modify proteins, enhancing their functionality and stability for various applications in biotechnology.
  • Diagnostic Tools: It plays a role in the development of diagnostic tools by aiding in the creation of peptide-based assays, which can be used for disease detection and monitoring.

Citations