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Catalog Number:
03724
CAS Number:
76265-70-8
Fmoc-L-methionine sulfoxide
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Met(O)-OH
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Product Information

Fmoc-L-methionine sulfoxide is a valuable derivative of the amino acid methionine, widely recognized for its role in peptide synthesis and research applications. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which enhances its stability and solubility, making it an ideal choice for solid-phase peptide synthesis. Researchers appreciate its utility in the synthesis of peptides with specific functionalities, particularly in the development of pharmaceuticals and biologically active compounds. The sulfoxide group not only contributes to the compound's unique properties but also allows for the introduction of oxidation states that can be crucial in various biochemical pathways.

In addition to its applications in peptide synthesis, Fmoc-L-methionine sulfoxide serves as a key building block in the design of novel therapeutics and biomolecules. Its ability to undergo selective reactions opens up possibilities for creating complex structures that are essential in drug discovery and development. This compound is particularly advantageous for researchers looking to explore the effects of methionine oxidation in biological systems, providing insights into protein function and stability. With its robust performance and versatility, Fmoc-L-methionine sulfoxide stands out as a critical tool for both academic and industrial applications.

Synonyms
Fmoc-L-Met(O)-OH
CAS Number
76265-70-8
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C20H21NO5S
Molecular Weight
387.5
MDL Number
MFCD00077064
PubChem ID
73137231
Melting Point
165 - 170 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -4 ± 2 º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Met(O)-OH
CAS Number
76265-70-8
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C20H21NO5S
Molecular Weight
387.5
MDL Number
MFCD00077064
PubChem ID
73137231
Melting Point
165 - 170 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -4 ± 2 º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-methionine sulfoxide is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and biologically active molecules.
  • Drug Development: Its role in medicinal chemistry is significant, as it helps in the design and optimization of peptide-based drugs, enhancing their efficacy and stability.
  • Bioconjugation: Fmoc-L-methionine sulfoxide can be used in bioconjugation processes, where it aids in attaching biomolecules to surfaces or other molecules, facilitating targeted drug delivery systems.
  • Protein Engineering: Researchers utilize this compound to modify proteins, improving their properties for various applications in biotechnology and pharmaceuticals.
  • Research in Oxidative Stress: It is valuable in studies related to oxidative stress, as it can mimic oxidative modifications in proteins, helping to understand their effects in biological systems.

Citations