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Catalog Number:
05737
CAS Number:
201004-46-8
N-Fmoc-N-palmitoyl-L-lysine
Purity:
≥ 97% (HPLC)
Synonym(s):
Fmoc-L-Lys(palmitoyl)-OH
Documents
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Product Information

Na-Fmoc-Ne-palmitoyl-L-lysine is a versatile compound widely utilized in peptide synthesis and bioconjugation applications. This amino acid derivative features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amines during the synthesis of peptides. The palmitoyl group enhances its hydrophobicity, making it particularly valuable in the development of lipid-based drug delivery systems and membrane-active peptides. Researchers in the fields of medicinal chemistry and biochemistry can leverage this compound to create more stable and effective therapeutic agents, especially in the design of targeted drug delivery systems that require enhanced cellular uptake.

In addition to its applications in drug formulation, Na-Fmoc-Ne-palmitoyl-L-lysine is also instrumental in the synthesis of peptide-based vaccines and therapeutics. Its unique structure allows for the incorporation of lipid moieties, which can improve the bioavailability and efficacy of peptide drugs. This compound stands out due to its ability to facilitate the formation of stable peptide conjugates, making it an essential tool for researchers aiming to innovate in the fields of immunology and cancer therapy.

Synonyms
Fmoc-L-Lys(palmitoyl)-OH
CAS Number
201004-46-8
Purity
≥ 97% (HPLC)
Molecular Formula
C37H54N2O5
Molecular Weight
606.85
MDL Number
MFCD00237026
PubChem ID
75627338
Melting Point
128 - 139 °C (Lit.)
Appearance
White to off-white or pale yellow powder
Optical Rotation
[a]D20 = 10 ± 4 º (C=1 in CHCl3)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Lys(palmitoyl)-OH
CAS Number
201004-46-8
Purity
≥ 97% (HPLC)
Molecular Formula
C37H54N2O5
Molecular Weight
606.85
MDL Number
MFCD00237026
PubChem ID
75627338
Melting Point
128 - 139 °C (Lit.)
Appearance
White to off-white or pale yellow powder
Optical Rotation
[a]D20 = 10 ± 4 º (C=1 in CHCl3)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Ne-palmitoyl-L-lysine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, enhancing the efficiency and yield of desired products.
  • Drug Delivery Systems: Its unique structure allows for the development of liposomal formulations, improving the delivery of therapeutic agents directly to target cells, which is crucial in cancer treatment.
  • Bioconjugation: It is employed in bioconjugation techniques to attach biomolecules to surfaces or other molecules, facilitating the creation of targeted drug delivery systems and diagnostic tools.
  • Research in Membrane Biology: The palmitoyl group enhances membrane interaction, making it useful in studies related to membrane proteins and cellular signaling pathways.
  • Cosmetic Formulations: Its properties are leveraged in the cosmetic industry for developing skin care products that promote hydration and skin barrier function, appealing to consumers seeking effective skincare solutions.

Citations