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Catalog Number:
05089
CAS Number:
198545-00-5
N-Fmoc-N-trimethylsilylethoxycarbonyl-D-lysine
Purity:
≥ 99% (HPLC, TLC)
Synonym(s):
Fmoc-D-Lys(Teoc)-OH
Documents
$99.85 /100MG
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Product Information

Na-Fmoc-Ne-trimethylsilylethoxycarbonyl-D-lysine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which is crucial for the selective protection of the amine group during the synthesis of complex peptides. Its unique trimethylsilylethoxycarbonyl (TMS-CO) moiety enhances solubility and stability, making it an excellent choice for researchers working with sensitive biological systems.

In practical applications, Na-Fmoc-Ne-trimethylsilylethoxycarbonyl-D-lysine is particularly beneficial in solid-phase peptide synthesis (SPPS), where it facilitates the formation of peptides with high purity and yield. Its ability to undergo selective deprotection allows for the efficient assembly of intricate peptide sequences, which are essential in the development of therapeutics and biologically active compounds. Researchers in the fields of medicinal chemistry and biochemistry will find this compound invaluable for creating novel peptides with tailored properties for drug discovery and development.

Synonyms
Fmoc-D-Lys(Teoc)-OH
CAS Number
198545-00-5
Purity
≥ 99% (HPLC, TLC)
Molecular Formula
C27H36N2O6Si
Molecular Weight
512.7
MDL Number
MFCD01075099
PubChem ID
14463612
Melting Point
70 - 75 °C
Appearance
White crystalline powder
Optical Rotation
[a]20D = 11 ± 1 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Lys(Teoc)-OH
CAS Number
198545-00-5
Purity
≥ 99% (HPLC, TLC)
Molecular Formula
C27H36N2O6Si
Molecular Weight
512.7
MDL Number
MFCD01075099
PubChem ID
14463612
Melting Point
70 - 75 °C
Appearance
White crystalline powder
Optical Rotation
[a]20D = 11 ± 1 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Ne-trimethylsilylethoxycarbonyl-D-lysine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids without interfering with other functional groups. This is crucial for researchers developing complex peptides for therapeutic applications.
  • Drug Development: It plays a significant role in the pharmaceutical industry, particularly in the design of peptide-based drugs. The ability to protect and deprotect specific amino acids enhances the efficiency of drug candidates, making them more viable for clinical use.
  • Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules. This is particularly beneficial in creating targeted drug delivery systems or diagnostic tools.
  • Protein Engineering: Researchers utilize this chemical in protein engineering to modify lysine residues, which can improve protein stability and functionality. This is essential in developing enzymes or antibodies with enhanced properties.
  • Research in Chemical Biology: It is a valuable tool in chemical biology for studying protein interactions and functions. By modifying lysine residues, scientists can investigate the role of specific amino acids in biological processes.

Citations