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Catalog Number:
03616
CAS Number:
146982-27-6
Nα-Fmoc-Nε-allyloxycarbonyl-L-lysine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Lys(Aloc)-OH
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Product Information

Na-Fmoc-Ne-allyloxycarbonyl-L-lysine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which is crucial for the selective protection of amino groups during the synthesis of peptides. Its unique allyloxycarbonyl group enhances reactivity and provides additional functionalization options, making it an excellent choice for researchers focused on developing complex peptide structures.

In the pharmaceutical industry, Na-Fmoc-Ne-allyloxycarbonyl-L-lysine is particularly valuable for the synthesis of peptide-based therapeutics, where precise control over amino acid sequences is essential. Its properties allow for efficient coupling reactions and facilitate the introduction of various side chains, enabling the design of peptides with tailored biological activities. Researchers benefit from its stability and compatibility with standard coupling reagents, streamlining the synthesis process and improving yields. This compound stands out for its ability to enhance the versatility of peptide synthesis, making it an indispensable tool for chemists and biochemists alike.

Synonyms
Fmoc-L-Lys(Aloc)-OH
CAS Number
146982-27-6
Purity
≥ 98% (HPLC)
Molecular Formula
C25H28N2O6
Molecular Weight
452.51
MDL Number
MFCD00190872
PubChem ID
3899900
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -12 ± 2 º (C=1 in DMF)
Conditions
Store at ≤ 4 °C
General Information
Synonyms
Fmoc-L-Lys(Aloc)-OH
CAS Number
146982-27-6
Purity
≥ 98% (HPLC)
Molecular Formula
C25H28N2O6
Molecular Weight
452.51
MDL Number
MFCD00190872
PubChem ID
3899900
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -12 ± 2 º (C=1 in DMF)
Conditions
Store at ≤ 4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Ne-allyloxycarbonyl-L-lysine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for selective reactions without interfering with other functional groups. Its stability under various conditions makes it a preferred choice for researchers in biochemistry.
  • Drug Development: In pharmaceutical research, it is used to create modified peptides that can enhance drug efficacy. By modifying lysine residues, scientists can improve the pharmacokinetics and bioavailability of therapeutic peptides.
  • Bioconjugation: The compound is valuable in bioconjugation techniques, where it facilitates the attachment of peptides to proteins or other biomolecules. This is crucial in developing targeted drug delivery systems and diagnostic tools.
  • Protein Engineering: Researchers utilize it in protein engineering to introduce specific modifications to lysine residues, thereby altering protein function or stability. This application is particularly relevant in the fields of synthetic biology and enzyme design.
  • Research on Post-Translational Modifications: It aids in studying post-translational modifications of proteins, which are essential for understanding cellular processes and disease mechanisms. By using this compound, researchers can mimic natural modifications and investigate their effects.

Citations