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Catalog Number:
02430
CAS Number:
159766-56-0
Nα-Fmoc-Nε-acetyl-L-lysine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Lys(Ac)-OH
Documents
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Product Information

Na-Fmoc-Ne-acetyl-L-lysine is a versatile amino acid derivative widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis of complex peptides, making it an essential building block for researchers in the fields of medicinal chemistry and biotechnology. Its acetylation at the amino group enhances solubility and stability, facilitating its use in various biochemical assays and processes.

This compound is particularly valuable in the development of peptide-based therapeutics and vaccines, where precise amino acid sequences are critical for biological activity. Researchers have leveraged Na-Fmoc-Ne-acetyl-L-lysine to create modified peptides that exhibit improved pharmacokinetic properties and enhanced biological functions. Its unique structure not only aids in the synthesis of diverse peptide libraries but also supports the exploration of novel therapeutic targets, making it a preferred choice for professionals seeking reliable and effective reagents in their work.

Synonyms
Fmoc-L-Lys(Ac)-OH
CAS Number
159766-56-0
Purity
≥ 98% (HPLC)
Molecular Formula
C23H26N2O5
Molecular Weight
410.5
MDL Number
MFCD00077409
Melting Point
155 - 165 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -13.5 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Lys(Ac)-OH
CAS Number
159766-56-0
Purity
≥ 98% (HPLC)
Molecular Formula
C23H26N2O5
Molecular Weight
410.5
MDL Number
MFCD00077409
Melting Point
155 - 165 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -13.5 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Ne-acetyl-L-lysine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in solid-phase peptide synthesis, allowing for the selective modification of amino acids without interfering with other functional groups.
  • Drug Development: Researchers use it to create peptide-based therapeutics, particularly in the development of targeted drug delivery systems that enhance efficacy and reduce side effects.
  • Bioconjugation: It is employed in bioconjugation techniques, facilitating the attachment of peptides to various biomolecules, which is crucial in the creation of diagnostic tools and therapeutic agents.
  • Protein Engineering: This chemical is instrumental in modifying lysine residues in proteins, enabling the design of proteins with enhanced stability and functionality for industrial applications.
  • Research in Cancer Therapy: Its application in synthesizing peptide inhibitors has shown promise in cancer research, where it aids in the development of compounds that can selectively target cancer cells.

Citations