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Catalog Number:
05728
CAS Number:
71989-25-8
Fmoc-L-leucine 4-nitrophenyl ester
Purity:
≥ 99% (TLC)
Synonym(s):
Fmoc-L-Leu-ONp, (S)-Fmoc-2-amino-4-methyl-pentanoic acid 4-nitrophenyl ester
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$29.34 /1G
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Product Information

Fmoc-L-leucine 4-nitrophenyl ester is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound serves as a protective group for the amino acid leucine, enabling chemists to selectively modify or couple it during the synthesis of complex peptides. Its unique structure, featuring the Fmoc (9-fluorenylmethoxycarbonyl) group, provides excellent stability under basic conditions while allowing for easy removal under mild acidic conditions, making it an ideal choice for researchers looking to streamline their synthesis processes.

In addition to its role in peptide synthesis, Fmoc-L-leucine 4-nitrophenyl ester is also employed in the development of pharmaceutical compounds, particularly in the creation of biologically active peptides. Its ability to enhance solubility and stability of peptide chains can lead to improved bioavailability and efficacy of therapeutic agents. Researchers in medicinal chemistry and biochemistry will find this compound invaluable for its efficiency and effectiveness in producing high-quality peptides for various applications, including drug discovery and development.

Synonyms
Fmoc-L-Leu-ONp, (S)-Fmoc-2-amino-4-methyl-pentanoic acid 4-nitrophenyl ester
CAS Number
71989-25-8
Purity
≥ 99% (TLC)
Molecular Formula
C27H26N2O6
Molecular Weight
474.51
MDL Number
MFCD00038536
PubChem ID
85978927
Melting Point
114-120 ?C
Appearance
Off-white powder
Optical Rotation
[a]D24 = -48 ± 2º (C=1% in dimethylformamide and 1% acetic acid)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-L-Leu-ONp, (S)-Fmoc-2-amino-4-methyl-pentanoic acid 4-nitrophenyl ester
CAS Number
71989-25-8
Purity
≥ 99% (TLC)
Molecular Formula
C27H26N2O6
Molecular Weight
474.51
MDL Number
MFCD00038536
PubChem ID
85978927
Melting Point
114-120 ?C
Appearance
Off-white powder
Optical Rotation
[a]D24 = -48 ± 2º (C=1% in dimethylformamide and 1% acetic acid)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-leucine 4-nitrophenyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides efficiently.
  • Drug Development: It is used in the development of peptide-based drugs, providing a means to modify peptide structures for enhanced therapeutic effects.
  • Bioconjugation: The compound facilitates the attachment of peptides to other biomolecules, which is crucial in creating targeted drug delivery systems.
  • Research in Protein Engineering: It aids in the study of protein interactions and modifications, helping scientists understand protein functions and develop novel proteins.
  • Analytical Chemistry: Fmoc-L-leucine 4-nitrophenyl ester is employed in various analytical techniques, including chromatography, to analyze peptide compositions and purities.

Citations