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Catalog Number:
04434
CAS Number:
74853-62-6
Nα,Nim-Ditrityl-L-histidine
Purity:
≥ 99% (TLC)
Synonym(s):
Trt-L-His(Trt)-OH
Documents
$45.47 /1G
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Product Information

Na,Nim-Ditrityl-L-histidine is a sophisticated amino acid derivative that serves as a valuable building block in peptide synthesis and drug development. This compound is particularly recognized for its role in enhancing the stability and solubility of peptides, making it an essential component in pharmaceutical formulations. Its unique trityl protecting groups provide excellent protection for the amino and imidazole side chains, allowing for selective deprotection during synthesis. Researchers and industry professionals utilize Na,Nim-Ditrityl-L-histidine in the development of targeted therapies, especially in oncology and immunology, where precise peptide sequences are crucial for efficacy.

Moreover, this compound's ability to facilitate the synthesis of complex peptides positions it as a preferred choice in the field of biochemistry and molecular biology. Its advantageous properties, such as improved yield and purity in peptide synthesis, make it a go-to option for laboratories focused on innovative drug discovery. With its robust profile, Na,Nim-Ditrityl-L-histidine not only streamlines the synthesis process but also enhances the overall quality of the final product, catering to the demands of modern pharmaceutical research.

Synonyms
Trt-L-His(Trt)-OH
CAS Number
74853-62-6
Purity
≥ 99% (TLC)
Molecular Formula
C44H37N3O2
Molecular Weight
639.8
MDL Number
MFCD00153443
PubChem ID
276751
Melting Point
183 - 203 ?C
Appearance
Off-white to yellow powder
Optical Rotation
[a]25D = 6.5 ± 2 ° (C=5 in Pyridin)
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Trt-L-His(Trt)-OH
CAS Number
74853-62-6
Purity
≥ 99% (TLC)
Molecular Formula
C44H37N3O2
Molecular Weight
639.8
MDL Number
MFCD00153443
PubChem ID
276751
Melting Point
183 - 203 ?C
Appearance
Off-white to yellow powder
Optical Rotation
[a]25D = 6.5 ± 2 ° (C=5 in Pyridin)
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na,Nim-Ditrityl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in peptide synthesis, allowing researchers to selectively modify amino acids without affecting others, thus streamlining the production of complex peptides.
  • Drug Development: It is used in the design of histidine-containing pharmaceuticals, enhancing the stability and bioavailability of drug candidates, particularly in the field of oncology.
  • Bioconjugation: The compound facilitates the attachment of biomolecules, such as antibodies and enzymes, to therapeutic agents, improving targeted delivery systems in cancer therapy.
  • Research in Protein Engineering: It aids in the study of protein folding and stability, providing insights that can lead to the development of more effective therapeutic proteins.
  • Analytical Chemistry: Na,Nim-Ditrityl-L-histidine is employed in chromatography and mass spectrometry, helping researchers analyze complex mixtures with high precision.

Citations