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Catalog Number:
04050
CAS Number:
69541-68-0
Nα-Boc-Nim-4-toluenesylfonyl-D-histidine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Boc-D-His(Tos)-OH
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Product Information

Na-Boc-Nim-4-toluenesylfonyl-D-histidine is a versatile compound widely utilized in the field of peptide synthesis and medicinal chemistry. This protected amino acid derivative features a Boc (tert-butyloxycarbonyl) group, which enhances its stability and solubility, making it an ideal candidate for various synthetic applications. Its unique sulfonyl group contributes to its reactivity, allowing for selective modifications in peptide sequences. Researchers often employ this compound in the development of peptide-based therapeutics, particularly in the design of inhibitors and modulators for biological targets.

Additionally, Na-Boc-Nim-4-toluenesylfonyl-D-histidine serves as a valuable building block in the synthesis of complex molecules, facilitating the creation of novel compounds with potential pharmaceutical applications. Its ability to undergo various coupling reactions while maintaining structural integrity makes it a preferred choice among chemists. With its robust profile and practical applications, this compound is essential for advancing research in drug discovery and development.

Synonyms
Boc-D-His(Tos)-OH
CAS Number
69541-68-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C18H23N3O6S
Molecular Weight
409.5
MDL Number
MFCD00037890
PubChem ID
4618294
Melting Point
119 - 130 ?C
Appearance
White to off-white yellowish powder
Optical Rotation
[a]D20 = -16 ± 3 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-D-His(Tos)-OH
CAS Number
69541-68-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C18H23N3O6S
Molecular Weight
409.5
MDL Number
MFCD00037890
PubChem ID
4618294
Melting Point
119 - 130 ?C
Appearance
White to off-white yellowish powder
Optical Rotation
[a]D20 = -16 ± 3 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Boc-Nim-4-toluenesylfonyl-D-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in creating modified peptides with enhanced stability and bioactivity, which are essential in drug development.
  • Drug Design: It plays a critical role in the design of pharmaceutical agents, especially in targeting specific biological pathways, making it valuable in the pharmaceutical industry for developing new therapies.
  • Bioconjugation: The compound is used in bioconjugation techniques, allowing researchers to attach biomolecules to drugs or imaging agents, improving their efficacy and targeting capabilities in therapeutic applications.
  • Research in Cancer Therapy: Its unique properties make it suitable for developing targeted cancer therapies, where precision in drug delivery is crucial for minimizing side effects and maximizing treatment efficacy.
  • Protein Engineering: This chemical is utilized in protein engineering to modify amino acid sequences, enhancing the functionality and stability of proteins for various applications in biotechnology and medicine.

Citations