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Catalog Number:
03372
CAS Number:
4467-54-3
D-His-OMe·2HCl
Purity:
≥ 98% (HPLC)
Synonym(s):
D-Histidine methyl ester dihydrochloride
Documents
$18.53 /1G
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Product Information

D-His-OMe·2HCl is a highly valuable compound recognized for its role as a building block in peptide synthesis and pharmaceutical research. This dihydrochloride salt of methyl (2R)-2-amino-3-(1H-imidazol-5-yl)propanoate is particularly useful in the development of bioactive peptides and drug candidates, especially in the fields of oncology and neurology. Its unique structure, featuring an imidazole side chain, enhances its potential for mimicking natural peptides, making it an essential tool for researchers aiming to design novel therapeutics.

The compound's solubility in water and stability under physiological conditions further contribute to its appeal in laboratory settings. D-His-OMe·2HCl is often employed in the synthesis of histidine-containing peptides, which are known for their antioxidant properties and ability to facilitate metal ion binding, thus broadening its application in biochemistry and molecular biology. Researchers and industry professionals will find this compound indispensable for advancing their work in peptide chemistry and drug development.

Synonyms
D-Histidine methyl ester dihydrochloride
CAS Number
4467-54-3
Purity
≥ 98% (HPLC)
Molecular Formula
C7H11N3O2· 2HCl
Molecular Weight
242.11
MDL Number
MFCD00066137
PubChem ID
12658396
Melting Point
208-212 ?C (dec)
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -10 ± 2º (C=1 in H2O)
Conditions
Store at 0-8 °C
General Information
Synonyms
D-Histidine methyl ester dihydrochloride
CAS Number
4467-54-3
Purity
≥ 98% (HPLC)
Molecular Formula
C7H11N3O2· 2HCl
Molecular Weight
242.11
MDL Number
MFCD00066137
PubChem ID
12658396
Melting Point
208-212 ?C (dec)
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -10 ± 2º (C=1 in H2O)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

D-His-OMe·2HCl is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly those that require histidine residues. Its incorporation can enhance the biological activity of therapeutic peptides.
  • Drug Development: In pharmaceutical research, it is used to create novel drug candidates, especially in the development of compounds targeting histamine receptors, which are crucial in allergy and gastric acid regulation.
  • Biochemical Assays: D-His-OMe·2HCl is employed in various biochemical assays to study enzyme activity and protein interactions, providing insights into cellular processes and potential therapeutic targets.
  • Research in Neuroscience: The compound is beneficial in neuroscience studies, particularly in exploring the role of histidine in neurotransmission and its implications in neurological disorders.
  • Custom Peptide Libraries: It is used in the creation of custom peptide libraries for high-throughput screening, allowing researchers to identify peptides with desired biological properties efficiently.

Citations