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Catalog Number:
02874
CAS Number:
135610-90-1
Nα-Fmoc-Nim-trityl-D-histidine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-His(Trt)-OH
Documents
$40.30 /1G
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Product Information

Na-Fmoc-Nim-trityl-D-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which facilitates the selective coupling of amino acids during the synthesis of complex peptides. Its unique trityl group enhances stability and solubility, making it an ideal choice for researchers focused on developing high-purity peptides for therapeutic applications.

In the pharmaceutical industry, Na-Fmoc-Nim-trityl-D-histidine is particularly valuable for creating peptide-based drugs that target specific biological pathways. Its application extends to the synthesis of peptide ligands, which are crucial in drug discovery and development. Researchers appreciate its ease of use and the efficiency it brings to the synthesis process, allowing for the rapid production of high-quality peptides. This compound stands out for its ability to improve yields and reduce side reactions, making it a preferred choice for professionals in the field.

Synonyms
Fmoc-D-His(Trt)-OH
CAS Number
135610-90-1
Purity
≥ 99% (HPLC)
Molecular Formula
C40H33N3O4
Molecular Weight
619.7
MDL Number
MFCD00077061
PubChem ID
4072357
Melting Point
130 - 180 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -80 ± 8 º (C=1 in CHCl3)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-His(Trt)-OH
CAS Number
135610-90-1
Purity
≥ 99% (HPLC)
Molecular Formula
C40H33N3O4
Molecular Weight
619.7
MDL Number
MFCD00077061
PubChem ID
4072357
Melting Point
130 - 180 ?C
Appearance
White powder
Optical Rotation
[a]D20 = -80 ± 8 º (C=1 in CHCl3)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-trityl-D-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and functional peptide chains.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing peptide-based drugs, which can target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The compound is used in bioconjugation techniques, enabling the attachment of peptides to various biomolecules, which is crucial for creating targeted drug delivery systems.
  • Research in Cancer Therapy: Researchers utilize it in studies aimed at developing novel cancer therapies, as peptides derived from this compound can inhibit tumor growth and improve patient outcomes.
  • Protein Engineering: It is instrumental in protein engineering applications, where modifications to histidine residues can enhance protein stability and functionality, benefiting various biotechnological processes.

Citations