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Catalog Number:
02705
CAS Number:
61070-20-0
Boc-His(1-Me)-OH
Purity:
≥ 99% (HPLC)
Synonym(s):
Boc-L-His(Nim-Me)-OH, Boc-His(τ-Me)-OH
Documents
$181.67 /100MG
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Product Information

Boc-His(1-Me)-OH is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a Boc (tert-butyloxycarbonyl) protecting group, which enhances its stability and solubility, making it an ideal choice for researchers working on complex peptide sequences. Its unique structure, characterized by the presence of a 1-methylimidazole side chain, contributes to its effectiveness in various biochemical applications, including the design of enzyme inhibitors and receptor ligands.

In the pharmaceutical industry, Boc-His(1-Me)-OH plays a crucial role in the development of therapeutic peptides, particularly those targeting specific biological pathways. Its ability to facilitate the formation of peptide bonds while maintaining the integrity of sensitive functional groups makes it a preferred reagent in synthetic chemistry. Researchers appreciate its versatility and efficiency, as it streamlines the synthesis process and improves yields in peptide production. With its robust profile, Boc-His(1-Me)-OH is an essential tool for advancing research in medicinal chemistry and biochemistry.

Synonyms
Boc-L-His(Nim-Me)-OH, Boc-His(τ-Me)-OH
CAS Number
61070-20-0
Purity
≥ 99% (HPLC)
Molecular Formula
C12H19N3O4
Molecular Weight
269.3
MDL Number
MFCD00076944
PubChem ID
21935430
Appearance
White to off white powder
Conditions
Store at 0-8°C
General Information
Synonyms
Boc-L-His(Nim-Me)-OH, Boc-His(τ-Me)-OH
CAS Number
61070-20-0
Purity
≥ 99% (HPLC)
Molecular Formula
C12H19N3O4
Molecular Weight
269.3
MDL Number
MFCD00076944
PubChem ID
21935430
Appearance
White to off white powder
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-His(1-Me)-OH is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly those containing histidine. Its protective Boc group allows for selective reactions, enhancing the efficiency of peptide assembly.
  • Drug Development: In pharmaceutical research, it is used to create histidine-containing compounds that may have therapeutic effects, particularly in the development of drugs targeting metabolic disorders.
  • Bioconjugation: The compound is employed in bioconjugation techniques, where it helps attach biomolecules to surfaces or other molecules, facilitating the development of targeted drug delivery systems.
  • Research in Enzyme Inhibition: Boc-His(1-Me)-OH is useful in studying enzyme activity and inhibition, particularly in the context of histidine's role in enzyme catalysis, providing insights into biochemical pathways.
  • Protein Engineering: It is applied in the field of protein engineering to modify histidine residues, allowing researchers to tailor protein properties for specific applications, such as improving stability or activity.

Citations