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Catalog Number:
02481
CAS Number:
159631-28-4
Nα-Fmoc-Nim-Boc-D-histidine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-His(Boc)-OH
Documents
$121.78 /1G
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Product Information

Na-Fmoc-Nim-Boc-D-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique combination of protective groups that enhance its stability and reactivity, making it an ideal choice for researchers engaged in the synthesis of complex peptides. Its fluorenylmethoxycarbonyl (Fmoc) and tert-butoxycarbonyl (Boc) protecting groups allow for selective deprotection, facilitating the stepwise assembly of peptides while minimizing side reactions.

In the pharmaceutical industry, Na-Fmoc-Nim-Boc-D-histidine is particularly valuable for developing peptide-based therapeutics, where precise control over amino acid sequences is crucial. Its application extends to the creation of biologically active compounds, including those targeting specific receptors or enzymes. Researchers appreciate its ability to improve the solubility and stability of peptides, which is essential for enhancing bioavailability and efficacy in drug formulations. With its robust profile and practical applications, Na-Fmoc-Nim-Boc-D-histidine stands out as a key reagent in modern peptide chemistry.

Synonyms
Fmoc-D-His(Boc)-OH
CAS Number
159631-28-4
Purity
≥ 98% (HPLC)
Molecular Formula
C26H27N3O6
Molecular Weight
477.5
MDL Number
MFCD00151927
Melting Point
141 - 145 ?C (Lit.)
Appearance
White powder
Optical Rotation
[a]D24 = 31 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-His(Boc)-OH
CAS Number
159631-28-4
Purity
≥ 98% (HPLC)
Molecular Formula
C26H27N3O6
Molecular Weight
477.5
MDL Number
MFCD00151927
Melting Point
141 - 145 ?C (Lit.)
Appearance
White powder
Optical Rotation
[a]D24 = 31 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-Boc-D-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, particularly in the development of therapeutic proteins and vaccines, enhancing the efficiency of the process.
  • Drug Development: It plays a significant role in drug formulation, especially in creating targeted therapies for various diseases, including cancer, by improving the stability and bioavailability of active pharmaceutical ingredients.
  • Bioconjugation: The compound is used in bioconjugation techniques, allowing researchers to attach drugs or imaging agents to biomolecules, which is essential in developing targeted drug delivery systems.
  • Research in Biochemistry: It aids in studying protein interactions and functions, providing insights into cellular processes, which is vital for understanding diseases and developing new treatments.
  • Custom Synthesis: Due to its unique properties, it is often employed in custom synthesis projects, enabling researchers to create tailored compounds for specific applications in various fields, including materials science and nanotechnology.

Citations