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Catalog Number:
01574
CAS Number:
35899-43-5
Nα-Boc-Nim-4-toluenesylfonyl-L-histidine
Purity:
≥ 98% (HPLC)
Synonym(s):
Boc-L-His(Tos)-OH
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Product Information

Na-Boc-Nim-4-toluenesylfonyl-L-histidine is a versatile compound widely utilized in the field of peptide synthesis and medicinal chemistry. This compound features a protective Boc (tert-butyloxycarbonyl) group, which enhances its stability and solubility, making it an ideal choice for researchers engaged in the development of peptide-based therapeutics. Its unique structure, characterized by the incorporation of a toluenesulfonyl group, allows for selective reactions that are crucial in the synthesis of complex biomolecules.

This compound is particularly beneficial in the synthesis of histidine-containing peptides, which are essential in various biological processes and have applications in drug development. Researchers can leverage Na-Boc-Nim-4-toluenesylfonyl-L-histidine to create novel peptide sequences that may exhibit enhanced biological activity or specificity. Its ability to facilitate the introduction of functional groups while maintaining the integrity of the peptide backbone makes it a valuable tool for chemists and biochemists alike.

Synonyms
Boc-L-His(Tos)-OH
CAS Number
35899-43-5
Purity
≥ 98% (HPLC)
Molecular Formula
C18H23N3O6S
Molecular Weight
409.5
MDL Number
MFCD00065967
Melting Point
113-132 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +16 ± 3º (C=1 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Boc-L-His(Tos)-OH
CAS Number
35899-43-5
Purity
≥ 98% (HPLC)
Molecular Formula
C18H23N3O6S
Molecular Weight
409.5
MDL Number
MFCD00065967
Melting Point
113-132 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +16 ± 3º (C=1 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Boc-Nim-4-toluenesylfonyl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for selective reactions without interfering with other functional groups. This is crucial in developing complex biomolecules.
  • Drug Development: Its unique structure makes it valuable in designing novel pharmaceuticals, particularly in creating inhibitors for specific biological targets, enhancing drug efficacy.
  • Bioconjugation: It is used in bioconjugation processes to attach biomolecules to surfaces or other molecules, which is essential in creating targeted drug delivery systems and diagnostic tools.
  • Research in Cancer Therapeutics: The compound is being explored for its potential in cancer treatment, particularly in creating targeted therapies that minimize side effects compared to traditional chemotherapy.
  • Protein Engineering: It aids in the modification of proteins to improve their stability and activity, which is vital in biotechnology and therapeutic applications.

Citations