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Catalog Number:
11956
CAS Number:
182410-75-9
Fmoc-S-acetamidomethyl-L-cysteine N-hydroxysuccinimide ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Cys(Acm)-OSu
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Product Information

Fmoc-S-acetamidomethyl-L-cysteine N-hydroxysuccinimide ester is a versatile compound widely utilized in peptide synthesis and bioconjugation applications. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which is essential for the selective protection of the amino group during the synthesis of peptides. Its unique structure allows for the introduction of a thiol group, making it particularly valuable in the development of peptide-based therapeutics and targeted drug delivery systems. Researchers appreciate its ability to facilitate the formation of disulfide bonds, enhancing the stability and functionality of peptide constructs.

In addition to its role in peptide synthesis, Fmoc-S-acetamidomethyl-L-cysteine N-hydroxysuccinimide ester is also employed in the modification of biomolecules, such as proteins and antibodies, enabling the creation of conjugates for diagnostic and therapeutic purposes. Its ease of use and compatibility with various reaction conditions make it a preferred choice among professionals in the fields of medicinal chemistry and biochemistry. This compound not only streamlines the synthesis process but also improves the overall efficiency of creating complex biomolecular structures.

Synonyms
Fmoc-L-Cys(Acm)-OSu
CAS Number
182410-75-9
Purity
≥ 98% (HPLC)
Molecular Formula
C25H25N3O7S
Molecular Weight
511.54
MDL Number
MFCD01076143
PubChem ID
132939346
Melting Point
145-153 °C
Appearance
Off-white powder
Optical Rotation
[a]D20 = -57 ± 2º (C=1 in DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-L-Cys(Acm)-OSu
CAS Number
182410-75-9
Purity
≥ 98% (HPLC)
Molecular Formula
C25H25N3O7S
Molecular Weight
511.54
MDL Number
MFCD01076143
PubChem ID
132939346
Melting Point
145-153 °C
Appearance
Off-white powder
Optical Rotation
[a]D20 = -57 ± 2º (C=1 in DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-S-acetamidomethyl-L-cysteine N-hydroxysuccinimide ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound is essential in the solid-phase synthesis of peptides, allowing for the incorporation of cysteine residues, which are crucial for forming disulfide bonds in protein structures.
  • Bioconjugation: It serves as an effective linker in bioconjugation processes, facilitating the attachment of biomolecules such as antibodies to drugs, enhancing targeted delivery in therapeutic applications.
  • Drug Development: The compound is used in the development of novel pharmaceuticals, particularly in creating compounds that require specific cysteine modifications for improved efficacy and stability.
  • Analytical Chemistry: It plays a role in the preparation of labeled compounds for analytical techniques, aiding in the detection and quantification of biomolecules in complex mixtures.
  • Research in Proteomics: The compound is valuable in proteomics studies, allowing researchers to modify proteins for better characterization and understanding of their functions in biological systems.

Citations