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Catalog Number:
03699
CAS Number:
177582-21-7
Fmoc-S-4-methoxytrityl-L-cysteine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Cys(Mmt)-OH
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Product Information

Fmoc-S-4-methoxytrityl-L-cysteine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (fluorenylmethyloxycarbonyl) group, which is crucial for the selective deprotection of amines during solid-phase peptide synthesis. Its unique structure, characterized by the presence of a methoxytrityl group, enhances stability and solubility, making it an excellent choice for researchers looking to optimize their synthetic pathways.

In practical applications, Fmoc-S-4-methoxytrityl-L-cysteine is particularly valuable in the production of peptides with specific functionalities, such as those used in therapeutic agents or as research tools in biochemistry. Its ability to facilitate the incorporation of cysteine residues into peptides allows for the formation of disulfide bonds, which are essential for the structural integrity of many biologically active peptides. This compound stands out for its ease of use and efficiency in synthesis, making it a preferred choice for professionals in pharmaceutical and academic research settings.

Synonyms
Fmoc-L-Cys(Mmt)-OH
CAS Number
177582-21-7
Purity
≥ 99% (HPLC)
Molecular Formula
C38H33NO5S
Molecular Weight
615.7
MDL Number
MFCD00270541
PubChem ID
53395978
Melting Point
117 - 127 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 12 - 16 º (C=1 in THF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Cys(Mmt)-OH
CAS Number
177582-21-7
Purity
≥ 99% (HPLC)
Molecular Formula
C38H33NO5S
Molecular Weight
615.7
MDL Number
MFCD00270541
PubChem ID
53395978
Melting Point
117 - 127 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 12 - 16 º (C=1 in THF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-S-4-methoxytrityl-L-cysteine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the efficient assembly of complex peptide sequences.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing peptide-based drugs, enhancing the stability and bioavailability of therapeutic agents.
  • Bioconjugation: Researchers use this chemical for bioconjugation processes, linking peptides to other biomolecules, which is crucial in creating targeted drug delivery systems.
  • Diagnostics: It is employed in the development of diagnostic tools, such as peptide-based assays, which can improve the detection of diseases through specific biomarker identification.
  • Research in Protein Engineering: This compound aids in the modification of proteins, allowing scientists to study protein interactions and functions, which is essential in understanding various biological processes.

Citations