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Catalog Number:
02065
CAS Number:
167015-11-4
Fmoc-S-trityl-D-cysteine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Cys(Trt)-OH
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Product Information

Fmoc-S-trityl-D-cysteine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. Known for its protective Fmoc (9-fluorenylmethyloxycarbonyl) group, this compound allows for selective deprotection, facilitating the assembly of complex peptides. Its trityl group enhances stability and solubility, making it an excellent choice for researchers focusing on the synthesis of thiol-containing peptides, which are crucial in various biological applications, including enzyme catalysis and drug design.

In addition to its role in peptide synthesis, Fmoc-S-trityl-D-cysteine is also valuable in the development of bioconjugates and targeted drug delivery systems. Its unique properties enable the formation of disulfide bonds, which are essential for maintaining the structural integrity of proteins and peptides. Researchers in medicinal chemistry and biochemistry can leverage this compound to create innovative therapeutic agents, enhancing their efficacy and specificity. With its robust performance in diverse applications, Fmoc-S-trityl-D-cysteine stands out as a key reagent for advancing peptide chemistry and drug discovery.

Synonyms
Fmoc-D-Cys(Trt)-OH
CAS Number
167015-11-4
Purity
≥ 98% (HPLC)
Molecular Formula
C37H31NO4S
Molecular Weight
585.7
MDL Number
MFCD00151922
Melting Point
170 - 180 ºC
Appearance
White powder
Optical Rotation
[a]D20 = -20 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Cys(Trt)-OH
CAS Number
167015-11-4
Purity
≥ 98% (HPLC)
Molecular Formula
C37H31NO4S
Molecular Weight
585.7
MDL Number
MFCD00151922
Melting Point
170 - 180 ºC
Appearance
White powder
Optical Rotation
[a]D20 = -20 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-S-trityl-D-cysteine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group for cysteine residues during peptide synthesis, allowing for the selective modification of other amino acids without interfering with the thiol group.
  • Drug Development: Its role in the synthesis of peptide-based drugs is crucial, particularly in creating compounds that target specific biological pathways, enhancing therapeutic efficacy.
  • Bioconjugation: The chemical is used in bioconjugation techniques, facilitating the attachment of drugs or imaging agents to proteins, which is vital in developing targeted therapies and diagnostic tools.
  • Research in Biochemistry: It aids in studying protein folding and interactions, providing insights into cellular processes and disease mechanisms, which is essential for developing new treatments.
  • Material Science: The compound is explored for its potential in creating novel materials, such as hydrogels or nanomaterials, which can be used in drug delivery systems or biosensors.

Citations