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Catalog Number:
04035
CAS Number:
132388-68-2
Nα-Boc-Nγ-trityl-L-asparagine
Purity:
≥ 98% (HPLC)
Synonym(s):
Boc-L-Asn(Trt)-OH
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Product Information

Na-Boc-Ng-trityl-L-asparagine is a versatile amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a protective Boc (tert-butyloxycarbonyl) group, which enhances its stability and reactivity, making it an ideal choice for the synthesis of complex peptides. Its unique trityl group provides additional protection for the amino group, facilitating selective reactions and improving yields in various synthetic pathways. Researchers appreciate its role in the development of bioactive peptides and therapeutic agents, particularly in the fields of drug discovery and development.

The compound's ability to undergo selective deprotection allows for the strategic assembly of peptides with specific functionalities, enabling the exploration of structure-activity relationships in medicinal chemistry. Na-Boc-Ng-trityl-L-asparagine is especially valuable in the synthesis of peptide-based drugs and can be employed in the production of peptide libraries for high-throughput screening. Its favorable properties and compatibility with various coupling reagents make it a preferred choice for chemists aiming to optimize peptide synthesis processes.

Synonyms
Boc-L-Asn(Trt)-OH
CAS Number
132388-68-2
Purity
≥ 98% (HPLC)
Molecular Formula
C28H30N2O5
Molecular Weight
474.6
MDL Number
MFCD00153299
PubChem ID
5060151
Melting Point
180 - 200 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -20 ± 2 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-L-Asn(Trt)-OH
CAS Number
132388-68-2
Purity
≥ 98% (HPLC)
Molecular Formula
C28H30N2O5
Molecular Weight
474.6
MDL Number
MFCD00153299
PubChem ID
5060151
Melting Point
180 - 200 ?C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -20 ± 2 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Boc-Ng-trityl-L-asparagine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing chemists to selectively modify amino acids without affecting others, thus streamlining the production of complex peptides.
  • Drug Development: It plays a crucial role in the development of pharmaceutical compounds, particularly in the design of novel therapeutics that target specific biological pathways, enhancing drug efficacy.
  • Bioconjugation: Researchers use it for bioconjugation processes, where it helps attach biomolecules to drugs or imaging agents, improving the specificity and effectiveness of treatments.
  • Protein Engineering: The compound is essential in protein engineering, allowing scientists to create modified proteins with enhanced stability and activity for various applications, including enzyme design.
  • Research in Neuroscience: It is utilized in studies related to neurotransmitter signaling, aiding in the understanding of neurological pathways and potential treatments for neurodegenerative diseases.

Citations